TNFRSF18, TNF receptor superfamily member 18

TNFRSF18, TNF receptor superfamily member 18

• This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]

• Gene Synonyms (tumor necrosis factor receptor superfamily member 18, TNF receptor superfamily activation-inducible protein, activation-inducible TNFR family receptor, glucocorticoid-induced TNFR-related protein, AITR, CD357, ENERGEN, GITR, GITR-D,)
• NCBI Gene ID: 8784
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y5U5
  UNIPROT ID#>>A0A0R7FDM1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TNF receptor superfamily member 18 interacts with:

• ligand of numb-protein X 1
  SIVA1 apoptosis inducing factor
  TNF receptor superfamily member 18
  TNF superfamily member 18
  ubiquilin 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.