UBA3, ubiquitin like modifier activating enzyme 3

UBA3, ubiquitin like modifier activating enzyme 3

• The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 subunit 2, NEDD8-activating enzyme E1C, Nedd8-activating enzyme hUba3, UBA3, ubiquitin-activating enzyme E1 homolog, ubiquitin-activating enzyme 3, ubiquitin-activating enzyme E1C (UBA3 homolog, yeast), ubiquitin-activating enzyme E1C (homologous to yeast UBA3), NAE2, UBE1C, hUBA3,)
• NCBI Gene ID: 9039
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8TBC4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin like modifier activating enzyme 3 interacts with:

• 3'-phosphoadenosine 5'-phosphosulfate synthase 1
  5'-nucleotidase domain containing 1
  anaphase promoting complex subunit 13
  APAF1 interacting protein
  autophagy related 7
  calcium/calmodulin dependent protein kinase ID
  COP9 signalosome subunit 2
  COP9 signalosome subunit 4
  COP9 signalosome subunit 5
  copine 2
  decapping enzyme, scavenger
  destrin, actin depolymerizing factor
  dual specificity phosphatase 23
  LEO1 homolog, Paf1/RNA polymerase II complex component
  lysine demethylase 1A
  NSFL1 cofactor
  NudC domain containing 2
  pelota mRNA surveillance and ribosome rescue factor
  potassium channel tetramerization domain containing 10
  thioredoxin domain containing 17
  ubiquitin conjugating enzyme E2 F (putative)
  ubiquitin conjugating enzyme E2 M
  ubiquitin interaction motif containing 1
  ubiquitin like modifier activating enzyme 3
  ubiquitin-fold modifier conjugating enzyme 1
  WD repeat domain 61
  zinc finger and BTB domain containing 44

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.