CYTH2, cytohesin 2

CYTH2, cytohesin 2

• The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

• Gene Synonyms (cytohesin-2, ARF exchange factor, ARF nucleotide-binding site opener, CTC-273B12.8, PH, SEC7 and coiled-coil domain-containing protein 2, pleckstrin homology, Sec7 and coiled-coil domains 2, pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2), ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like, cytohesin-2,)
• NCBI Gene ID: 9266
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99418
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cytohesin 2 interacts with:

• ADP ribosylation factor GTPase activating protein 1
  ADP ribosylation factor like GTPase 4A
  ATPase H+ transporting V0 subunit a2
  ATPase H+ transporting V0 subunit a4
  coiled-coil domain containing 120
  coiled-coil domain containing 40
  connector enhancer of kinase suppressor of Ras 1
  cytohesin 1 interacting protein
  golgi associated, gamma adaptin ear containing, ARF binding protein 3
  innate immunity activator
  interaction protein for cytohesin exchange factors 1
  patatin like phospholipase domain containing 2
  T cell immune regulator 1, ATPase H+ transporting V0 subunit a3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.