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EIF2AK3, eukaryotic translation initiation factor 2 alpha kinase 3

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EIF2AK3, eukaryotic translation initiation factor 2 alpha kinase 3

  • The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]

  • Gene Synonyms (eukaryotic translation initiation factor 2-alpha kinase 3, PRKR-like endoplasmic reticulum kinase, pancreatic EIF2-alpha kinase, truncated eukaryotic translation initiation factor 2 alpha kinase 3, PEK, PERK, WRS,)
  • NCBI Gene ID: 9451
  • Species: Homo sapiens (Human)
  • UNIPROT ID#>>Q68DI6
    UNIPROT ID#>>Q9NZJ5
    UNIPROT ID#>>E7ER02
    UNIPROT ID#>>B3KY45
  • View the NCBI Database for this Gene »

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

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The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

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