TLK1, tousled like kinase 1

TLK1, tousled like kinase 1

• The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

• Gene Synonyms (serine/threonine-protein kinase tousled-like 1, SNARE protein kinase SNAK, serine threonine protein kinase, PKU-beta,)
• NCBI Gene ID: 9874
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UKI8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tousled like kinase 1 interacts with:

• anti-silencing function 1A histone chaperone
  anti-silencing function 1B histone chaperone
  basic helix-loop-helix family member b9
  basic leucine zipper ATF-like transcription factor 3
  BEN domain containing 7
  developmental pluripotency associated 4
  dynein light chain LC8-type 1
  dynein light chain LC8-type 2
  exportin 7
  leucine zipper protein 4
  PIN2 (TERF1) interacting telomerase inhibitor 1
  RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
  spermatogenesis associated 1
  tousled like kinase 1
  tousled like kinase 2
  ubiquitin like with PHD and ring finger domains 2
  YY1 associated factor 2
  zinc finger and SCAN domain containing 22
  zinc finger protein 655
  zinc finger protein 773
  zinc finger protein 829

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.