SEM1, SEM1 26S proteasome complex subunit

SEM1, SEM1 26S proteasome complex subunit

• The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle. [provided by RefSeq, Jul 2008]

• Gene Synonyms (26S proteasome complex subunit SEM1, 26S proteasome complex subunit DSS1, deleted in split hand/split foot protein 1, deleted in split-hand/split-foot 1, split hand/foot deleted protein 1, split hand/foot malformation (ectrodactyly) type 1, split hand/foot malformation type 1 protein, C7orf76, DSS1, ECD, SHFD1, SHFM1, SHSF1, Shfdg1,)
• NCBI Gene ID: 7979
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6IBB7
  UNIPROT ID#>>P60896
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SEM1 26S proteasome complex subunit interacts with:

• adhesion regulating molecule 1
  BAG cochaperone 2
  BAG cochaperone 3
  coiled-coil domain containing 39
  cullin 1
  cullin 2
  cullin 4B
  cytoskeleton associated protein 5
  DEAD-box helicase 42
  dynein axonemal intermediate chain 3
  Ecm29 proteasome adaptor and scaffold
  eukaryotic translation initiation factor 3 subunit A
  eukaryotic translation initiation factor 3 subunit C
  F-box protein 7
  HECT domain E3 ubiquitin protein ligase 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  integrator complex subunit 10
  integrator complex subunit 11
  integrator complex subunit 2
  integrator complex subunit 4
  integrator complex subunit 5
  integrator complex subunit 6
  integrator complex subunit 7
  integrator complex subunit 8
  integrator complex subunit 9
  leukocyte receptor cluster member 8
  listerin E3 ubiquitin protein ligase 1
  membrane associated ring-CH-type finger 6
  microtubule associated protein 1 light chain 3 beta
  midasin AAA ATPase 1
  negative regulator of ubiquitin like proteins 1
  NSFL1 cofactor
  nuclear prelamin A recognition factor
  nudix hydrolase 21
  ORC ubiquitin ligase 1
  PCI domain containing 2
  pre-mRNA processing factor 4B
  proline rich coiled-coil 2C
  proteasomal ATPase associated factor 1
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 6
  proteasome activator subunit 3
  proteasome activator subunit 4
  proteasome assembly chaperone 1
  proteasome assembly chaperone 2
  proteasome assembly chaperone 3
  proteasome inhibitor subunit 1
  proteasome maturation protein
  protein inhibitor of activated STAT 1
  ribosome production factor 2 homolog
  ring finger protein 126
  ring finger protein 181
  RNA binding motif protein 15B
  RNA binding motif protein 33
  SAC3 domain containing 1
  SIN3 transcription regulator family member A
  staphylococcal nuclease and tudor domain containing 1
  STIP1 homology and U-box containing protein 1
  talin 2
  thioredoxin like 1
  tripartite motif containing 33
  ubiquilin 1
  ubiquilin 2
  ubiquilin 4
  ubiquitin C-terminal hydrolase L5
  ubiquitin family domain containing 1
  ubiquitin like 4A
  ubiquitin like domain containing CTD phosphatase 1
  ubiquitin protein ligase E3 component n-recognin 1
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin protein ligase E3 component n-recognin 7
  ubiquitin protein ligase E3B
  ubiquitin protein ligase E3C
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 38
  zinc finger AN1-type containing 2B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.