CUL4B, cullin 4B

CUL4B, cullin 4B

• This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (cullin-4B, CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2,)
• NCBI Gene ID: 8450
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13620
  UNIPROT ID#>>K4DI93
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cullin 4B interacts with:

• 5'-3' exoribonuclease 2
  actin beta like 2
  Aly/REF export factor
  ankyrin repeat and SOCS box containing 6
  ankyrin repeat domain 39
  ATP binding cassette subfamily F member 2
  AT-rich interaction domain 4B
  autophagy and beclin 1 regulator 1
  BAG cochaperone 3
  bromodomain and WD repeat domain containing 3
  bromodomain and WD repeat domain containing 3
  bromodomain containing 4
  caseinolytic mitochondrial matrix peptidase chaperone subunit X
  CDC42 effector protein 4
  cell division cycle associated 8
  cereblon
  chromatin licensing and DNA replication factor 1
  chromobox 1
  chromobox 3
  chromobox 5
  cilia and flagella associated protein 157
  cleavage and polyadenylation specific factor 2
  cleavage and polyadenylation specific factor 6
  cleavage and polyadenylation specific factor 7
  cleavage stimulation factor subunit 2 tau variant
  coiled-coil domain containing 120
  coiled-coil domain containing 80
  component of oligomeric golgi complex 4
  COP1 E3 ubiquitin ligase
  COP9 signalosome subunit 2
  COP9 signalosome subunit 3
  COP9 signalosome subunit 4
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  COP9 signalosome subunit 7A
  COP9 signalosome subunit 7B
  COP9 signalosome subunit 8
  COP9 signalosome subunit 9
  copper chaperone for superoxide dismutase
  copper metabolism domain containing 1
  cullin 2
  cullin 3
  cullin 4A
  cullin 4B
  cullin associated and neddylation dissociated 1
  damage specific DNA binding protein 1
  DAZ associated protein 1
  DDB1 and CUL4 associated factor 1
  DDB1 and CUL4 associated factor 10
  DDB1 and CUL4 associated factor 11
  DDB1 and CUL4 associated factor 12 like 2
  DDB1 and CUL4 associated factor 13
  DDB1 and CUL4 associated factor 15
  DDB1 and CUL4 associated factor 16
  DDB1 and CUL4 associated factor 17
  DDB1 and CUL4 associated factor 4
  DDB1 and CUL4 associated factor 4 like 1
  DDB1 and CUL4 associated factor 4 like 2
  DDB1 and CUL4 associated factor 6
  DDB1 and CUL4 associated factor 7
  DDB1 and CUL4 associated factor 8
  DEAD-box helicase 17
  DEAD-box helicase 18
  DEAD-box helicase 56
  dedicator of cytokinesis 8
  dedicator of cytokinesis 9
  defective in cullin neddylation 1 domain containing 1
  defective in cullin neddylation 1 domain containing 2
  defective in cullin neddylation 1 domain containing 3
  defective in cullin neddylation 1 domain containing 4
  defective in cullin neddylation 1 domain containing 5
  denticleless E3 ubiquitin protein ligase
  denticleless E3 ubiquitin protein ligase homolog
  dermcidin
  DET1 and DDB1 associated 1
  DET1 partner of COP1 E3 ubiquitin ligase
  developmental pluripotency associated 3
  DExD-box helicase 21
  DExD-box helicase 50
  DExH-box helicase 30
  DLG associated protein 3
  DNA polymerase alpha 2, accessory subunit
  DnaJ heat shock protein family (Hsp40) member C10
  dpy-19 like 4
  dual specificity phosphatase 15
  dynein 2 intermediate chain 2
  enhancer of polycomb homolog 2
  erbb2 interacting protein
  establishment of sister chromatid cohesion N-acetyltransferase 2
  eukaryotic translation initiation factor 5A2
  family with sequence similarity 184 member A
  far upstream element binding protein 1
  Fas binding factor 1
  F-box and WD repeat domain containing 11
  F-box protein 44
  FKBP prolyl isomerase 8
  forkhead box P1
  fructosamine 3 kinase related protein
  G protein nucleolar 2
  G protein nucleolar 3
  gamma-glutamyltransferase light chain family member 3
  GAR1 ribonucleoprotein
  glomulin, FKBP associated protein
  glucosaminyl (N-acetyl) transferase 3, mucin type
  glutamate rich WD repeat containing 1
  glutaminyl-peptide cyclotransferase
  golgi integral membrane protein 4
  GRB10 interacting GYF protein 2
  H2A clustered histone 11
  H2A clustered histone 12
  H2A.Z variant histone 2
  H2B clustered histone 18
  H3 clustered histone 15
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heterochromatin protein 1 binding protein 3
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein C like 1
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein R
  heterogeneous nuclear ribonucleoprotein U like 1
  high mobility group nucleosomal binding domain 4
  HMG-box transcription factor 1
  insulin like growth factor 2 mRNA binding protein 1
  insulin receptor substrate 4
  intraflagellar transport 122
  keratin 24
  keratin 71
  keratin 75
  keratin 76
  KH RNA binding domain containing, signal transduction associated 1
  KH-type splicing regulatory protein
  kinase suppressor of ras 1
  kinesin family member 15
  kinesin family member C2
  KRR1 small subunit processome component homolog
  kynurenine aminotransferase 3
  La ribonucleoprotein 1, translational regulator
  LDL receptor related protein 1B
  lemur tyrosine kinase 3
  leucine rich pentatricopeptide repeat containing
  lysine demethylase 4D
  matrin 3
  MCF.2 cell line derived transforming sequence like
  metadherin
  methylcrotonoyl-CoA carboxylase 1
  microtubule associated monooxygenase, calponin and LIM domain containing 1
  mindbomb E3 ubiquitin protein ligase 1
  mitochondrial ribosomal protein S11
  MTSS I-BAR domain containing 1
  MYC binding protein 2
  myocardin related transcription factor A
  myosin XVIIIA
  myotubularin related protein 12
  NBPF member 8
  NEDD4 binding protein 1
  NLR family pyrin domain containing 1
  NLR family pyrin domain containing 3
  NOP58 ribonucleoprotein
  nuclear receptor binding SET domain protein 1
  nuclear RNA export factor 1
  nucleolar complex associated 4 homolog
  nucleolar protein 6
  nucleoporin 153
  nucleoporin 160
  nucleoporin 210
  nucleotide binding protein like
  nudix hydrolase 16 like 1
  nudix hydrolase 21
  Opa interacting protein 5
  oxysterol binding protein like 8
  paraspeckle component 1
  parkin coregulated
  peroxiredoxin 3
  peter pan homolog
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  pleckstrin homology domain containing A4
  pleckstrin homology domain interacting protein
  POC1 centriolar protein B
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  poly(ADP-ribose) polymerase family member 12
  POM121 and ZP3 fusion
  POM121 transmembrane nucleoporin C
  POP7 homolog, ribonuclease P/MRP subunit
  prohibitin 2
  protein arginine methyltransferase 5
  protein phosphatase 6 regulatory subunit 1
  RBMX like 1
  RBMX like 2
  RBMX like 3
  receptor accessory protein 1
  receptor for activated C kinase 1
  RecQ like helicase 4
  regulator of chromosome condensation 2
  regulator of G protein signaling 14
  regulatory associated protein of MTOR complex 1
  required for meiotic nuclear division 5 homolog A
  ribosomal protein L14
  ribosomal protein L26 like 1
  ribosomal protein L35
  ring finger protein 7
  ring-box 1
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding motif protein 14
  RNA binding motif protein 22
  RNA binding motif protein 25
  RNA binding motif protein 39
  RNA binding motif protein X-linked
  RNA guanine-7 methyltransferase activating subunit
  RNA transcription, translation and transport factor
  RUN and SH3 domain containing 2
  RWD domain containing 4
  scaffold attachment factor B2
  SDS3 homolog, SIN3A corepressor complex component
  sec1 family domain containing 1
  secernin 1
  serine and arginine repetitive matrix 1
  serine and arginine rich splicing factor 10
  serine and arginine rich splicing factor 11
  serine/arginine repetitive matrix 2
  SET and MYND domain containing 2
  sideroflexin 1
  SIN3 transcription regulator family member A
  Sin3A associated protein 130
  Sin3A associated protein 30
  sirtuin 7
  small nuclear ribonucleoprotein U5 subunit 40
  SMU1 DNA replication regulator and spliceosomal factor
  SNW domain containing 1
  spermatid perinuclear RNA binding protein
  SPHK1 interactor, AKAP domain containing
  spliceosome associated factor 3, U4/U6 recycling protein
  splicing regulatory glutamic acid and lysine rich protein 1
  StAR related lipid transfer domain containing 7
  STIP1 homology and U-box containing protein 1
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  tau tubulin kinase 1
  terminal uridylyl transferase 4
  testin LIM domain protein
  thioredoxin interacting protein
  TNF alpha induced protein 8
  torsin 1A interacting protein 1
  torsin 1A interacting protein 2
  trafficking from ER to golgi regulator
  transcription elongation factor A like 2
  transducin beta like 3
  transformer 2 alpha homolog
  transient receptor potential cation channel subfamily C member 4 associated protein
  translocase of outer mitochondrial membrane 20
  transmembrane and coiled-coil domains 3
  transmembrane protein 109
  transmembrane protein 33
  transmembrane protein 43
  transmembrane serine protease 7
  tubulin alpha 1b
  tubulin alpha 1c
  tubulin alpha 4b
  tubulin beta 1 class VI
  tubulin beta 4B class IVb
  tubulin beta class I
  tubulin tyrosine ligase like 7
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 M
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin protein ligase E3C
  ubiquitin specific peptidase 10
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 19
  ubiquitin specific peptidase 25
  UBX domain protein 7
  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
  vitamin K epoxide reductase complex subunit 1
  VPS16 core subunit of CORVET and HOPS complexes
  WD and tetratricopeptide repeats 1
  WD repeat domain 26
  WD repeat domain 48
  WD repeat domain 5
  WD repeat domain 54
  WD repeat domain 5B
  WD repeat domain 61
  WD repeat domain 62
  WD repeat domain 76
  WD repeat domain 77
  WD repeat domain 82
  WD repeat domain, phosphoinositide interacting 2
  X-box binding protein 1
  Y-box binding protein 3
  ZFP64 zinc finger protein
  zinc finger and BTB domain containing 47
  zinc finger matrin-type 4
  zinc finger protein 582

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.