UBA2, ubiquitin like modifier activating enzyme 2

UBA2, ubiquitin like modifier activating enzyme 2

• Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

• Gene Synonyms (SUMO-activating enzyme subunit 2, SUMO-1 activating enzyme subunit 2, SUMO1 activating enzyme subunit 2, UBA2, ubiquitin-activating enzyme E1 homolog, anthracycline-associated resistance ARX, ubiquitin-like 1-activating enzyme E1B, ARX, HRIHFB2115, SAE2,)
• NCBI Gene ID: 10054
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UBT2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin like modifier activating enzyme 2 interacts with:

• 2-oxoglutarate and iron dependent oxygenase domain containing 1
  adenosine deaminase tRNA specific 2
  adenosylhomocysteinase like 1
  arginine and glutamate rich 1
  ariadne RBR E3 ubiquitin protein ligase 1
  ataxin 10
  B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
  biogenesis of ribosomes BRX1
  cactin, spliceosome C complex subunit
  catenin beta like 1
  CCR4-NOT transcription complex subunit 1
  cell division cycle 73
  cell division cycle associated 8
  centromere protein P
  centrosomal protein 162
  charged multivesicular body protein 2A
  charged multivesicular body protein 5
  chloride intracellular channel 4
  COPI coat complex subunit epsilon
  copine 5
  derlin 1
  dual specificity phosphatase 28
  dynactin subunit 2
  EFR3 homolog A
  EH domain containing 4
  ER degradation enhancing alpha-mannosidase like protein 3
  forkhead box K1
  golgi transport 1B
  GPN-loop GTPase 3
  integrator complex subunit 5
  lebercilin LCA5
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leucyl-tRNA synthetase 1
  lipoic acid synthetase
  lysine demethylase 1A
  mediator complex subunit 9
  mitotic spindle organizing protein 1
  NOP58 ribonucleoprotein
  NPL4 homolog, ubiquitin recognition factor
  NSE1 homolog, SMC5-SMC6 complex component
  Parkinsonism associated deglycase
  PCF11 cleavage and polyadenylation factor subunit
  PDZ and LIM domain 5
  perilipin 3
  phosphodiesterase 12
  phosphopantothenoylcysteine synthetase
  pleckstrin homology domain containing A4
  PNN interacting serine and arginine rich protein
  progesterone receptor membrane component 1
  protein arginine methyltransferase 5
  RAD18 E3 ubiquitin protein ligase
  RNA binding motif protein 17
  RNA exonuclease 2
  RTF1 homolog, Paf1/RNA polymerase II complex component
  SEH1 like nucleoporin
  selenophosphate synthetase 2
  SERPINE1 mRNA binding protein 1
  shootin 1
  SPOUT domain containing methyltransferase 1
  stathmin 2
  structural maintenance of chromosomes 5
  sulfiredoxin 1
  SUMO1 activating enzyme subunit 1
  target of myb1 like 2 membrane trafficking protein
  TELO2 interacting protein 2
  testis expressed 101
  tetratricopeptide repeat domain 9C
  THADA armadillo repeat containing
  transcription elongation factor A like 4
  transforming acidic coiled-coil containing protein 3
  tripartite motif containing 28
  tubulin gamma complex associated protein 5
  ubiquilin 2
  ubiquitin like modifier activating enzyme 2
  ubiquitin-conjugating enzyme E2I
  unk zinc finger
  WD repeat domain 11
  WD repeat domain 70
  Yes1 associated transcriptional regulator
  YTH domain containing 1
  zinc finger CCHC-type containing 9
  zinc finger FYVE-type containing 19
  zinc finger HIT-type containing 6
  zinc finger protein 511

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.