MAPK8IP3, mitogen-activated protein kinase 8 interacting protein 3

MAPK8IP3, mitogen-activated protein kinase 8 interacting protein 3

• The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (JIP-3, JIP3, JSAP1, NEDBA, SYD2, syd, C-Jun-amino-terminal kinase-interacting protein 3, C-jun-amino-terminal kinase interacting protein 3, JNK MAP kinase scaffold protein 3, JNK-interacting protein 3, JNK/SAPK-associated protein-1, JNK/stress-activated protein kinase-associated protein 1, homolog of Drosophila Sunday driver 2,)
• NCBI Gene ID: 23162
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A087WYG2
  UNIPROT ID#>>B7ZMF3
  UNIPROT ID#>>Q9UPT6
  UNIPROT ID#>>E9PFH7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase 8 interacting protein 3 interacts with:

• actin related protein 10
  dynactin subunit 4
  kinesin light chain 2
  low density lipoprotein receptor adaptor protein 1
  mitogen-activated protein kinase 8 interacting protein 2
  mitogen-activated protein kinase 8 interacting protein 3
  RCC1 domain containing 1
  RIC8 guanine nucleotide exchange factor A
  single-pass membrane protein with coiled-coil domains 1
  sulfotransferase family 4A member 1
  tankyrase 2
  toll like receptor 9
  WD repeat domain 54
  zinc finger protein 575

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.