PLAGL1, PLAG1 like zinc finger 1

PLAGL1, PLAG1 like zinc finger 1

• This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]

• Gene Synonyms (zinc finger protein PLAGL1, PLAG-like 1, lost on transformation 1, pleiomorphic adenoma gene-like 1, tumor suppressor ZAC, LOT1, ZAC, ZAC1,)
• NCBI Gene ID: 5325
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A1YLA1
  UNIPROT ID#>>A1YLA2
  UNIPROT ID#>>Q9UM63
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

PLAG1 like zinc finger 1 interacts with:

• lysine acetyltransferase 2B
  PLAG1 like zinc finger 1
  PML nuclear body scaffold
  protein inhibitor of activated STAT 2
  small ubiquitin like modifier 1
  tripartite motif containing 25
  tumor protein p53
  tumor protein p73
  ubiquitin conjugating enzyme E2 I

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.