TP73, tumor protein p73

TP73, tumor protein p73

• This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]

• Gene Synonyms (tumor protein p73, p53-like transcription factor, p53-related protein, P73,)
• NCBI Gene ID: 7161
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0C4DFW9
  UNIPROT ID#>>O15350
  UNIPROT ID#>>A0A024R4C3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tumor protein p73 interacts with:

• A-kinase anchoring protein 1
  anti-silencing function 1A histone chaperone
  argonaute RISC catalytic component 2
  argonaute RISC component 1
  assembly factor for spindle microtubules
  ATP/GTP binding protein like 2
  bromodomain containing 8
  CCAAT enhancer binding protein zeta
  Cdk5 and Abl enzyme substrate 1
  chromatin licensing and DNA replication factor 1
  chromosome 6 open reading frame 141
  cilia and flagella associated protein 206
  cullin 1
  DAB2 interacting protein
  DEAD-box helicase 23
  death associated protein kinase 2
  DENN domain containing 4A
  DnaJ heat shock protein family (Hsp40) member B6
  DSN1 component of MIS12 kinetochore complex
  dynamin 3
  exportin 1
  F-box protein 45
  glutaminase 2
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  homeodomain interacting protein kinase 2
  homeodomain interacting protein kinase 3
  immediate early response 2
  insulin like growth factor 2 mRNA binding protein 1
  itchy E3 ubiquitin protein ligase
  junctophilin 1
  L3MBTL histone methyl-lysine binding protein 1
  leucine rich pentatricopeptide repeat containing
  lysine acetyltransferase 2B
  lysine acetyltransferase 5
  lysine demethylase 1A
  mediator complex subunit 15
  methenyltetrahydrofolate synthetase domain containing
  mitochondrial E3 ubiquitin protein ligase 1
  myosin light chain 9
  NEDD4 binding protein 2
  NPR3 like, GATOR1 complex subunit
  nuclear pore complex interacting protein family, member B13
  piwi like RNA-mediated gene silencing 1
  protein arginine methyltransferase 6
  protein inhibitor of activated STAT 1
  protein phosphatase 1 regulatory subunit 13B
  RAB, member of RAS oncogene family like 2A
  RAN binding protein 9
  receptor for activated C kinase 1
  ring finger and CHY zinc finger domain containing 1
  ring finger protein 38
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  SAS-6 centriolar assembly protein
  sirtuin 1
  small ubiquitin like modifier 1
  splA/ryanodine receptor domain and SOCS box containing 1
  STIP1 homology and U-box containing protein 1
  stromal antigen 1
  trafficking protein particle complex 11
  tripartite motif containing 28
  tripartite motif containing 32
  tRNA methyltransferase 11 homolog
  tropomyosin 3
  tubulin tyrosine ligase like 5
  tumor protein p53 regulated apoptosis inducing protein 1
  tumor protein p63
  tumor protein p73
  tyrosine kinase non receptor 2
  ubiquitin conjugating enzyme E2 D3
  ubiquitin conjugating enzyme E2 I
  ubiquitination factor E4B
  WT1 transcription factor
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  Yes1 associated transcriptional regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.