PTGDS, prostaglandin D2 synthase

PTGDS, prostaglandin D2 synthase

• The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

• Gene Synonyms (prostaglandin-H2 D-isomerase, PGD2 synthase, beta-trace protein, cerebrin-28, glutathione-independent PGD synthase, glutathione-independent PGD synthetase, lipocalin-type prostaglandin D synthase, prostaglandin D synthase, prostaglandin D2 synthase 21kDa (brain), testis tissue sperm-binding protein Li 63n, L-PGDS, LPGDS, PDS, PGD2, PGDS, PGDS2,)
• NCBI Gene ID: 5730
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P41222
  UNIPROT ID#>>A0A024R8G3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

prostaglandin D2 synthase interacts with:

• ataxin 1
  caspase recruitment domain family member 10
  cysteine rich tail 1
  F-box and WD repeat domain containing 7
  keratin associated protein 10-3
  keratin associated protein 10-7
  keratin associated protein 12-3
  phospholipase A and acyltransferase 4
  prostaglandin D2 synthase
  prostaglandin E receptor 1
  prostaglandin E receptor 2
  prostaglandin F receptor
  sex hormone binding globulin
  ubiquilin 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.