MAP2K4, mitogen-activated protein kinase kinase 4

MAP2K4, mitogen-activated protein kinase kinase 4

• This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

• Gene Synonyms (dual specificity mitogen-activated protein kinase kinase 4, JNK-activated kinase 1, JNK-activating kinase 1, MAP kinase kinase 4, MAPK/ERK kinase 4, MAPKK 4, MEK 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, stress-activated protein kinase kinase 1, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1,)
• NCBI Gene ID: 6416
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P45985
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase kinase 4 interacts with:

• B cell linker
  CASP8 and FADD like apoptosis regulator
  filamin, alpha
  gem nuclear organelle associated protein 5
  itchy E3 ubiquitin protein ligase
  KTI12 chromatin associated homolog
  leucine rich repeat kinase 2
  mitogen-activated protein kinase 8 interacting protein 3
  mitogen-activated protein kinase kinase 4
  mitogen-activated protein kinase kinase kinase 12
  mitogen-activated protein kinase kinase kinase 14
  mitogen-activated protein kinase kinase kinase 2
  mitogen-activated protein kinase kinase kinase 20
  mitogen-activated protein kinase kinase kinase 7
  pleckstrin homology domain containing A4
  sperm associated antigen 9
  tribbles pseudokinase 1
  tripartite motif containing 25
  ubiquitin C
  vasodilator stimulated phosphoprotein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.