STAT4, signal transducer and activator of transcription 4

STAT4, signal transducer and activator of transcription 4

• The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

• Gene Synonyms (signal transducer and activator of transcription 4, signal transducer and activator of transcription 4 variant 3, SLEB11,)
• NCBI Gene ID: 6775
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14765
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

signal transducer and activator of transcription 4 interacts with:

• N-myc and STAT interactor
  PDZ and LIM domain 2
  protein inhibitor of activated STAT 2
  SH2 domain containing 1B
  signal transducer and activator of transcription 4
  transketolase
  tripartite motif containing 28
  zinc finger protein 467

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.