TFE3, transcription factor binding to IGHM enhancer 3

TFE3, transcription factor binding to IGHM enhancer 3

• This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

• Gene Synonyms (transcription factor E3, class E basic helix-loop-helix protein 33, transcription factor E family, member A, transcription factor for IgH enhancer, transcription factor for immunoglobulin heavy-chain enhancer 3, RCCP2, RCCX1, TFEA, bHLHe33,)
• NCBI Gene ID: 7030
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DIA5
  UNIPROT ID#>>A0A024QZ23
  UNIPROT ID#>>P19532
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transcription factor binding to IGHM enhancer 3 interacts with:

• arrestin, beta 2
  cullin 2
  eukaryotic translation initiation factor 3 subunit A
  exportin 1
  H4 clustered histone 1
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
  prohibitin 2
  TAR DNA binding protein
  transcription factor binding to IGHM enhancer 3
  transcription factor EB
  transcription factor EC
  tripartite motif containing 28
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  valyl-tRNA synthetase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.