TSC2, TSC complex subunit 2

TSC2, TSC complex subunit 2

• Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

• Gene Synonyms (tuberin, protein phosphatase 1, regulatory subunit 160, tuberous sclerosis 2 protein, LAM, PPP1R160, TSC4,)
• NCBI Gene ID: 7249
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P49815
  UNIPROT ID#>>Q5HYF7
  UNIPROT ID#>>H3BMQ0
  UNIPROT ID#>>B3KWH7
  UNIPROT ID#>>X5D7Q2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TSC complex subunit 2 interacts with:

• ariadne RBR E3 ubiquitin protein ligase 2
  axin 1
  CD83 molecule
  chibby family member 1, beta catenin antagonist
  chibby family member 2
  coactivator associated arginine methyltransferase 1
  collagen type XX alpha 1 chain
  CTD phosphatase subunit 1
  cullin associated and neddylation dissociated 1
  cyclin dependent kinase 11A
  cytosolic iron-sulfur assembly component 1
  DDB1 and CUL4 associated factor 7
  family with sequence similarity 221 member B
  F-box and WD repeat domain containing 5
  HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  histone deacetylase 8
  insulin like growth factor 2 mRNA binding protein 1
  ligand of numb-protein X 1
  limb development membrane protein 1 like
  MAPK activated protein kinase 2
  metal response element binding transcription factor 2
  OTU deubiquitinase with linear linkage specificity
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  PNKD metallo-beta-lactamase domain containing
  polo like kinase 2
  prolyl 4-hydroxylase subunit alpha 2
  prolyl 4-hydroxylase subunit alpha 3
  RAB guanine nucleotide exchange factor 1
  rabaptin, RAB GTPase binding effector protein 1
  Ras related GTP binding A
  Ras related GTP binding B
  Ras related GTP binding C
  Ras related GTP binding D
  receptor interacting serine/threonine kinase 4
  ring finger protein 123
  RNA guanylyltransferase and 5'-phosphatase
  RPTOR independent companion of MTOR complex 2
  RuvB like AAA ATPase 2
  SEC23 interacting protein
  SEC24 homolog A, COPII coat complex component
  SEC24 homolog C, COPII coat complex component
  secretion associated Ras related GTPase 1A
  serine peptidase inhibitor, Kunitz type 2
  SIGLEC family like 1
  sirtuin 1
  solute carrier family 39 member 7
  solute carrier family 39 member 9
  TANK binding kinase 1
  TBC1 domain family member 7
  TBC1 domain family, member 7
  TNF superfamily member 13b
  TP53 induced glycolysis regulatory phosphatase
  trafficking protein particle complex 12
  trafficking protein particle complex 13
  trafficking protein particle complex 2 like
  TSC complex subunit 1
  TSC complex subunit 2
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin conjugating enzyme E2 J1
  ubiquitin protein ligase E3A
  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
  VPS53 subunit of GARP complex
  WD repeat domain 92

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.