MAPKAPK2, MAPK activated protein kinase 2

MAPKAPK2, MAPK activated protein kinase 2

• This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (MAP kinase-activated protein kinase 2, MAPKAP kinase 2, mitogen-activated protein kinase-activated protein kinase 2, MAPKAP-K2, MK-2, MK2,)
• NCBI Gene ID: 9261
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P49137
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MAPK activated protein kinase 2 interacts with:

• actin related protein 2/3 complex subunit 5
  argonaute RISC catalytic component 2
  BAG cochaperone 2
  centrosomal protein 131
  COP9 signalosome subunit 5
  eukaryotic elongation factor 2 kinase
  heat shock protein 1
  heterogeneous nuclear ribonucleoprotein A0
  MAPK activated protein kinase 2
  mitogen-activated protein kinase 14
  nuclear RNA export factor 1
  phospholipase A2 group IIE
  poly(A) binding protein cytoplasmic 1
  protein tyrosine phosphatase 4A3
  RCSD domain containing 1
  sphingosine kinase 2
  tripartite motif containing 28
  tripartite motif containing 29
  ubiquitin conjugating enzyme E2 J1
  ubiquitin-conjugating enzyme E2J 1
  zinc finger protein 36

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.