UBTF, upstream binding transcription factor

UBTF, upstream binding transcription factor

• This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]

• Gene Synonyms (nucleolar transcription factor 1, 90-kDa nucleolus organizer region autoantigen, autoantigen NOR-90, upstream binding transcription factor, RNA polymerase I, CONDBA, NOR-90, UBF, UBF-1, UBF1, UBF2,)
• NCBI Gene ID: 7343
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P17480
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

upstream binding transcription factor interacts with:

• activator of HSP90 ATPase activity 1
  adaptor related protein complex 3 subunit mu 1
  ATRX, chromatin remodeler
  autophagy related 16 like 1
  bromodomain and WD repeat domain containing 3
  bromodomain containing 7
  CaM kinase like vesicle associated
  CCR4-NOT transcription complex subunit 1
  cell division cycle 14B
  chromobox 1
  copine 7
  CTD small phosphatase 2
  cullin 4A
  cullin 7
  cyclic GMP-AMP synthase
  decapping enzyme, scavenger
  H3 clustered histone 15
  H4 clustered histone 1
  insulin receptor substrate 2
  La ribonucleoprotein 7, transcriptional regulator
  lymphoid enhancer binding factor 1
  lysine acetyltransferase 2B
  lysine acetyltransferase 5
  lysine rich nucleolar protein 1
  microspherule protein 1
  mitotic arrest deficient 1 like 1
  M-phase phosphoprotein 8
  MYB binding protein 1a
  NKAP domain containing 1
  NOP53 ribosome biogenesis factor
  NOP56 ribonucleoprotein
  obscurin like cytoskeletal adaptor 1
  pescadillo ribosomal biogenesis factor 1
  pyrin and HIN domain family member 1
  ribosome binding protein 1
  RNA polymerase I subunit A
  RNA polymerase I subunit E
  RNA polymerase I subunit G
  round spermatid basic protein 1
  RRN3 homolog, RNA polymerase I transcription factor
  RTF1 homolog, Paf1/RNA polymerase II complex component
  RuvB-like protein 1
  sirtuin 7
  SMAD specific E3 ubiquitin protein ligase 1
  SNF2 histone linker PHD RING helicase
  SUMO specific peptidase 3
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  TATA-box binding protein associated factor, RNA polymerase I subunit A
  TATA-box binding protein associated factor, RNA polymerase I subunit B
  TATA-box binding protein associated factor, RNA polymerase I subunit C
  TATA-box binding protein associated factor, RNA polymerase I subunit D
  tripartite motif containing 25
  upstream binding transcription factor
  vesicle transport through interaction with t-SNAREs 1B
  vimentin
  vir like m6A methyltransferase associated
  WD repeat domain 70
  WW domain containing E3 ubiquitin protein ligase 2
  YEATS domain containing 4
  zinc finger MYM-type containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.