MAPK8IP1, mitogen-activated protein kinase 8 interacting protein 1

MAPK8IP1, mitogen-activated protein kinase 8 interacting protein 1

• This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

• Gene Synonyms (C-Jun-amino-terminal kinase-interacting protein 1, IB-1, JNK MAP kinase scaffold protein 1, JNK-interacting protein 1, PRKM8 interacting protein, islet-brain 1, IB1, JIP-1, JIP1, PRKM8IP,)
• NCBI Gene ID: 9479
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6NUQ9
  UNIPROT ID#>>Q9UQF2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase 8 interacting protein 1 interacts with:

• dual specificity phosphatase 16
  fem-1 homolog B
  mitogen-activated protein kinase 8 interacting protein 1
  mitogen-activated protein kinase 8 interacting protein 2
  mitogen-activated protein kinase 8 interacting protein 3
  Parkinsonism associated deglycase
  Rho guanine nucleotide exchange factor 28
  senataxin
  SUMO specific peptidase 5
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  tubulin beta 3 class III
  tubulin tyrosine ligase like 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.