PLK4, polo like kinase 4

PLK4, polo like kinase 4

• This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

• Gene Synonyms (MCCRP2, SAK, STK18, serine/threonine-protein kinase PLK4, Snk akin kinase, serine/threonine-protein kinase 18, serine/threonine-protein kinase Sak,)
• NCBI Gene ID: 10733
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00444
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

polo like kinase 4 interacts with:

• CDK5 regulatory subunit associated protein 2
  centrosomal protein 128
  centrosomal protein 131
  centrosomal protein 152
  centrosomal protein 192
  centrosomal protein 250
  centrosomal protein 63
  centrosomal protein 85
  centrosome and spindle pole associated protein 1
  chromosome 1 open reading frame 109
  coiled-coil domain containing 15
  dedicator of cytokinesis 7
  DnaJ heat shock protein family (Hsp40) member B13
  dual specificity phosphatase 23
  endosome associated trafficking regulator 1
  family with sequence similarity 83 member H
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 5
  KIAA1671
  leucine zipper tumor suppressor 2
  microtubule associated scaffold protein 2
  mindbomb E3 ubiquitin protein ligase 1
  MYC binding protein 2
  NEDD1 gamma-tubulin ring complex targeting factor
  oxysterol binding protein like 3
  patatin like phospholipase domain containing 8
  polo like kinase 4
  PR/SET domain 16
  RNA binding fox-1 homolog 1
  SAS-6 centriolar assembly protein
  spindle and centriole associated protein 1
  stromal cell derived factor 4
  synaptopodin 2
  Tax1 binding protein 3
  terminal nucleotidyltransferase 5B
  terminal nucleotidyltransferase 5C
  tripartite motif containing 54
  tuftelin interacting protein 11
  ubiquitin specific peptidase 54
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.