MYCBP2, MYC binding protein 2

MYCBP2, MYC binding protein 2

• This gene encodes an E3 ubiquitin-protein ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect. [provided by RefSeq, Mar 2017]

• Gene Synonyms (Myc-bp2, PAM, PHR1, Phr, E3 ubiquitin-protein ligase MYCBP2, Highwire, MYC binding protein 2, E3 ubiquitin protein ligase, PAM/Highwire/RPM-1 protein 1, RING-type E3 ubiquitin transferase MYCBP2, myc-binding protein 2, pam/highwire/rpm-1 protein, protein associated with Myc,)
• NCBI Gene ID: 23077
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75592
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MYC binding protein 2 interacts with:

• acid phosphatase 7, tartrate resistant (putative)
  aldehyde dehydrogenase 1 family member L2
  ATPase cation transporting 13A2
  cadherin 19
  catenin alpha 3
  chromobox 2
  coiled-coil domain containing 158
  coiled-coil domain containing 65
  coiled-coil domain containing 8
  cyclic GMP-AMP synthase
  dedicator of cytokinesis 5
  DEF6 guanine nucleotide exchange factor
  egl-9 family hypoxia inducible factor 3
  F-box and WD repeat domain containing 7
  F-box protein 45
  hes related family bHLH transcription factor with YRPW motif 1
  histone deacetylase 11
  leucine rich repeat containing G protein-coupled receptor 4
  ligand of numb-protein X 1
  mediator complex subunit 4
  mex-3 RNA binding family member C
  myosin regulatory light chain interacting protein
  neuralized E3 ubiquitin protein ligase 4
  piggyBac transposable element derived 1
  pleckstrin homology domain containing A4
  protocadherin alpha 3
  sestrin 3
  sirtuin 7
  SLAIN motif family member 2
  spindle and kinetochore associated complex subunit 1
  sprouty-related EVH1 domain containing 2
  squamous cell carcinoma antigen recognized by T cells 3
  transmembrane p24 trafficking protein 10
  vir like m6A methyltransferase associated
  VPS26, retromer complex component B
  WD repeat domain 48

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.