DERL2, derlin 2

DERL2, derlin 2

• Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (derlin-2, Der1-like domain family, member 2, carcinoma related, degradation in endoplasmic reticulum protein 2, CGI-101, DERtrin-2, F-LAN-1, F-LANa, FLANa, derlin-2,)
• NCBI Gene ID: 51009
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9GZP9
  UNIPROT ID#>>I3L3R8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

derlin 2 interacts with:

• derlin 1
  diablo IAP-binding mitochondrial protein
  ER membrane protein complex subunit 3
  FXYD domain containing ion transport regulator 6
  keratin associated protein 10-3
  keratin associated protein 10-7
  keratin associated protein 10-8
  microtubule associated serine/threonine kinase like
  pleckstrin homology domain containing A4
  potassium channel tetramerisation domain containing 5
  reticulon 4
  ribosome binding factor A
  selenoprotein S
  SFT2 domain containing 1
  solute carrier family 15 member 3
  store-operated calcium entry associated regulatory factor
  synoviolin 1
  transmembrane protein 129, E3 ubiquitin ligase
  transmembrane protein 63B
  ubiquitin conjugating enzyme E2 J1
  unc-93 homolog B1, TLR signaling regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.