UCHL1, ubiquitin C-terminal hydrolase L1

UCHL1, ubiquitin C-terminal hydrolase L1

• The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]

• Gene Synonyms (ubiquitin carboxyl-terminal hydrolase isozyme L1, epididymis luminal protein 117, epididymis secretory protein Li 53, neuron cytoplasmic protein 9.5, ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase), ubiquitin thioesterase L1, ubiquitin thiolesterase, HEL-117, HEL-S-53, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, SPG79, Uch-L1,)
• NCBI Gene ID: 7345
• Species: Homo sapiens (Human)
• UNIPROT ID#>>V9HW74
  UNIPROT ID#>>P09936
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin C-terminal hydrolase L1 interacts with:

• apoptosis inducing factor mitochondria associated 1
  aryl hydrocarbon receptor interacting protein
  chloride intracellular channel 4
  chromobox 1
  coiled-coil domain containing 14
  COP9 signalosome subunit 5
  cullin 7
  derlin 1
  dimethylarginine dimethylaminohydrolase 1
  DNA polymerase delta interacting protein 2
  fumarylacetoacetate hydrolase domain containing 2A
  glutamine amidotransferase like class 1 domain containing 3A
  glyoxalase domain containing 4
  glyoxylate and hydroxypyruvate reductase
  GrpE like 1, mitochondrial
  haloacid dehalogenase like hydrolase domain containing 3
  histidine triad nucleotide binding protein 2
  IQ motif containing B1
  lactamase beta 2
  leucine rich repeat kinase 2
  NmrA like redox sensor 1
  Parkinsonism associated deglycase
  peroxiredoxin 6
  phosphoethanolamine/phosphocholine phosphatase 1
  pleckstrin homology domain containing A4
  protein phosphatase targeting COQ7
  pyruvate dehyrogenase phosphatase catalytic subunit 1
  RAN binding protein 9
  regulatory associated protein of MTOR complex 1
  succinate-CoA ligase ADP-forming subunit beta
  succinate-CoA ligase GDP/ADP-forming subunit alpha
  TERF1 interacting nuclear factor 2
  TERF2 interacting protein
  thioesterase superfamily member 4
  tripartite motif containing 54
  tripartite motif containing 63
  tubulin alpha 1a
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 21
  ubiquitin specific peptidase 28
  WD repeat domain 82

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.