GAN, gigaxonin

GAN, gigaxonin

• This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN). [provided by RefSeq, Oct 2008]

• Gene Synonyms (gigaxonin, epididymis secretory sperm binding protein, kelch-like family member 16, kelch-like protein 16, GAN1, GIG, KLHL16,)
• NCBI Gene ID: 8139
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z4W2
  UNIPROT ID#>>B3KTC3
  UNIPROT ID#>>Q9H2C0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

gigaxonin interacts with:

• actin beta like 2
  ankyrin repeat domain 36
  ankyrin repeat domain 36B
  ATPase family AAA domain containing 3A
  autophagy related 16 like 1
  BCL2 associated transcription factor 1
  calcium voltage-gated channel subunit alpha1 H
  capping protein regulator and myosin 1 linker 1
  CCAAT enhancer binding protein zeta
  cellular inhibitor of PP2A
  centrosomal protein 72
  centrosome and spindle pole associated protein 1
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 6B
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  chibby family member 1, beta catenin antagonist
  cilia and flagella associated protein 44
  ciliary rootlet coiled-coil, rootletin
  coiled-coil domain containing 73
  cullin 3
  cytoplasmic linker associated protein 1
  cytoplasmic polyadenylation element binding protein 1
  cytosolic thiouridylase subunit 1
  discs large MAGUK scaffold protein 5
  DnaJ heat shock protein family (Hsp40) member C10
  doublecortin domain containing 1
  dynein axonemal heavy chain 10
  dynein cytoplasmic 2 heavy chain 1
  dynein heavy chain domain 1
  eosinophil peroxidase
  eukaryotic elongation factor, selenocysteine-tRNA specific
  eukaryotic translation initiation factor 3 subunit A
  eukaryotic translation initiation factor 3 subunit B
  eukaryotic translation initiation factor 3 subunit C
  eukaryotic translation initiation factor 3 subunit D
  eukaryotic translation initiation factor 3 subunit I
  eukaryotic translation initiation factor 3 subunit L
  family with sequence similarity 126 member A
  G protein-coupled receptor 101
  gigaxonin
  glutamine rich 1
  helicase with zinc finger
  internexin neuronal intermediate filament protein alpha
  kelch repeat and BTB domain containing 8
  kinesin family member 21B
  lamin B2
  matrix remodeling associated 5
  microtubule associated serine/threonine kinase 2
  mitochondrial ribosomal protein L39
  mitogen-activated protein kinase kinase kinase kinase 3
  myosin heavy chain 14
  myosin XVIIIA
  ninein like
  nucleoporin 160
  NudC domain containing 3
  phospholipase C beta 1
  pleckstrin homology like domain family B member 1
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  poly(ADP-ribose) polymerase family member 14
  potassium channel tetramerization domain containing 5
  POTE ankyrin domain family member F
  pre-mRNA processing factor 31
  protein arginine methyltransferase 5
  PTEN induced kinase 1
  receptor for activated C kinase 1
  Rho guanine nucleotide exchange factor 1
  Rho guanine nucleotide exchange factor 12
  ring finger protein 213
  ring-box 1
  RIO kinase 1
  RNA binding motif protein 10
  rotatin
  semaphorin 5B
  serine/threonine kinase 38
  SET domain containing 2, histone lysine methyltransferase
  slingshot protein phosphatase 2
  spectrin beta, non-erythrocytic 5
  spectrin repeat containing nuclear envelope protein 1
  spectrin repeat containing nuclear envelope protein 2
  spindlin 1
  spindlin interactor and repressor of chromatin binding
  sterile alpha motif domain containing 4A
  syncoilin, intermediate filament protein
  tektin 1
  teneurin transmembrane protein 3
  thyroid hormone receptor associated protein 3
  TNF receptor associated protein 1
  transformation/transcription domain associated protein
  tubulin alpha 1b
  tubulin alpha 8
  tubulin beta 2B class IIb
  tubulin beta 3 class III
  tubulin beta 4A class IVa
  tubulin beta 4B class IVb
  tubulin beta 6 class V
  tubulin beta 8 class VIII
  tubulin beta class I
  valosin containing protein interacting protein 1
  vir like m6A methyltransferase associated
  WD repeat domain 76
  WD repeat domain 77
  zinc finger C3H1-type containing
  zinc finger CCCH-type containing 13
  zinc finger MYM-type containing 3
  zinc finger protein 469
  zinc finger protein 616
  zinc finger protein 618
  zinc finger ZZ-type and EF-hand domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.