ZMPSTE24, zinc metallopeptidase STE24

ZMPSTE24, zinc metallopeptidase STE24

• This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008]

• Gene Synonyms (FACE-1, FACE1, HGPS, PRO1, STE24, Ste24p, CAAX prenyl protease 1 homolog, farnesylated proteins-converting enzyme 1, prenyl protein-specific endoprotease 1, zinc metallopeptidase STE24 homolog, zinc metalloproteinase Ste24 homolog,)
• NCBI Gene ID: 10269
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75844
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

zinc metallopeptidase STE24 interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  armadillo repeat containing X-linked 3
  ATPase H+ transporting V1 subunit H
  dual specificity phosphatase 23
  gap junction protein beta 7
  glycerophosphodiester phosphodiesterase domain containing 5
  heterogeneous nuclear ribonucleoprotein U like 1
  KIAA2013
  mitochondrial ribosomal protein L40
  mitochondrial ribosomal protein S5
  OTU deubiquitinase with linear linkage specificity like
  pleckstrin homology domain containing A4
  polyamine modulated factor 1
  RAB10, member RAS oncogene family
  ring finger protein 26
  synaptojanin 2 binding protein
  tectonic family member 2
  tectonic family member 3
  translocase of outer mitochondrial membrane 6
  transmembrane protein 43
  transmembrane serine protease 12
  VAC14 component of PIKFYVE complex
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.