GCAT, glycine C-acetyltransferase

GCAT, glycine C-acetyltransferase

• The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14. [provided by RefSeq, Jan 2010]

• Gene Synonyms (2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial, 2-amino-3-ketobutyrate-CoA ligase, AKB ligase, aminoacetone synthase, glycine acetyltransferase, KBL,)
• NCBI Gene ID: 23464
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8K228
  UNIPROT ID#>>O75600
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glycine C-acetyltransferase interacts with:

• bromodomain containing 7
  ECSIT signaling integrator
  egl-9 family hypoxia inducible factor 3
  embigin
  F-box protein 6
  methylcrotonoyl-CoA carboxylase 1
  ninein
  pleckstrin homology domain containing A4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.