GAB1, GRB2 associated binding protein 1

GAB1, GRB2 associated binding protein 1

• The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

• Gene Synonyms (DFNB26, GRB2-associated-binding protein 1, GRB2-associated binder 1, deafness, autosomal recessive 26, growth factor receptor bound protein 2-associated protein 1, symbol withdrawn, see GAB1,)
• NCBI Gene ID: 2549
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9HA84
  UNIPROT ID#>>Q13480
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

GRB2 associated binding protein 1 interacts with:

• ADP ribosylation factor like GTPase 4C
  BAG cochaperone 3
  cullin 4B
  dynein light chain Tctex-type 1
  egl-9 family hypoxia inducible factor 3
  ezrin
  fibroblast growth factor receptor substrate 2
  G protein subunit alpha i3
  galectin 7
  general transcription factor IIA subunit 1 like
  GRB2 associated binding protein 2
  GRB2 related adaptor protein 2
  growth factor receptor bound protein 2
  HRas proto-oncogene, GTPase
  inositol polyphosphate-5-phosphatase D
  insulin receptor
  Janus kinase 1
  KRAS proto-oncogene, GTPase
  linker for activation of T cells family member 2
  macrophage stimulating 1 receptor
  MET proto-oncogene, receptor tyrosine kinase
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  mitogen-activated protein kinase 4
  mitogen-activated protein kinase kinase kinase 3
  neurotrophic receptor tyrosine kinase 1
  NRAS proto-oncogene, GTPase
  par-3 family cell polarity regulator
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  phosphofructokinase, platelet
  phosphoinositide-3-kinase regulatory subunit 1
  phospholipase C gamma 1
  phospholipase C gamma 2
  platelet derived growth factor receptor beta
  protein kinase C iota
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 18
  protein tyrosine phosphatase receptor type A
  ret proto-oncogene
  Rho associated coiled-coil containing protein kinase 1
  Rho GTPase activating protein 32
  SHC adaptor protein 1
  SOS Ras/Rac guanine nucleotide exchange factor 1
  synaptophysin
  tripartite motif containing 15
  Tu translation elongation factor, mitochondrial
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.