MAP3K3, mitogen-activated protein kinase kinase kinase 3

MAP3K3, mitogen-activated protein kinase kinase kinase 3

• This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

• Gene Synonyms (MAPKKK3, MEKK3, mitogen-activated protein kinase kinase kinase 3, MAP/ERK kinase kinase 3, MAPK/ERK kinase kinase 3, MEK kinase 3, MEKK 3,)
• NCBI Gene ID: 4215
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99759
  UNIPROT ID#>>J3KRN4
  UNIPROT ID#>>Q96HN9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase kinase kinase 3 interacts with:

• anaphase-promoting complex subunit 5
  cell division cycle 37, HSP90 cochaperone
  centrosomal protein 85
  chibby family member 1, beta catenin antagonist
  COP9 signalosome subunit 5
  cullin 7
  exportin 1
  glutaredoxin 3
  inositol hexakisphosphate kinase 3
  mitogen-activated protein kinase kinase 3
  mitogen-activated protein kinase kinase 4
  mitogen-activated protein kinase kinase 5
  mitogen-activated protein kinase kinase 7
  mitogen-activated protein kinase kinase kinase 2
  mitogen-activated protein kinase kinase kinase 3
  mitogen-activated protein kinase kinase kinase 5
  mitogen-activated protein kinase kinase kinase 7
  NEDD4 E3 ubiquitin protein ligase
  NEDD4 like E3 ubiquitin protein ligase
  NFKB inhibitor alpha
  p53 and DNA damage regulated 1
  prefoldin subunit 2
  protein kinase cAMP-activated catalytic subunit alpha
  protein phosphatase 2 catalytic subunit alpha
  receptor interacting serine/threonine kinase 1
  sequestosome 1
  SMAD specific E3 ubiquitin protein ligase 1
  sperm associated antigen 9
  target of myb1 like 1 membrane trafficking protein
  TNF receptor associated factor 6
  TNF receptor associated factor 7
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  vir like m6A methyltransferase associated
  von Willebrand factor
  WNK lysine deficient protein kinase 1
  zinc finger and BTB domain containing 16

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.