GIGYF2, GRB10 interacting GYF protein 2

GIGYF2, GRB10 interacting GYF protein 2

• This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

• Gene Synonyms (GRB10-interacting GYF protein 2, PERQ amino acid rich, with GYF domain 3, PERQ amino acid-rich with GYF domain-containing protein 2, Parkinson disease (autosomal recessive, early onset) 11, trinucleotide repeat-containing gene 15 protein, GYF2, PARK11, PERQ2, PERQ3, TNRC15,)
• NCBI Gene ID: 26058
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6Y7W6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

GRB10 interacting GYF protein 2 interacts with:

• argonaute RISC catalytic component 2
  centrosomal protein 76
  chromosome 10 open reading frame 88
  cingulin
  coiled-coil domain containing 8
  DENN domain containing 1A
  DENN domain containing 4C
  DIS3 like exosome 3'-5' exoribonuclease
  egl-9 family hypoxia inducible factor 3
  gem nuclear organelle associated protein 4
  GRB10 interacting GYF protein 1
  inositol polyphosphate-5-phosphatase E
  leucine rich repeat and fibronectin type III domain containing 1
  leucine rich repeat containing G protein-coupled receptor 4
  LIM domain and actin binding 1
  lipin 3
  MAPK associated protein 1
  mex-3 RNA binding family member C
  mindbomb E3 ubiquitin protein ligase 1
  mitogen-activated protein kinase kinase kinase 21
  NAD kinase
  neuron navigator 1
  ninein
  non-SMC condensin II complex subunit H2
  oxysterol binding protein like 6
  pleckstrin homology domain containing A4
  pleckstrin homology domain containing A7
  pleckstrin homology like domain family B member 2
  poly (ADP-ribose) glycohydrolase
  poly(A) binding protein cytoplasmic 1
  potassium channel tetramerization domain containing 3
  protein phosphatase, Mg2+/Mn2+ dependent 1H
  pyrin and HIN domain family member 1
  Ral GEF with PH domain and SH3 binding motif 2
  ribosomal protein L35
  ring finger and CCCH-type domains 2
  SH3 domain containing ring finger 3
  sirtuin 7
  tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
  TNFAIP3 interacting protein 2
  U2 small nuclear RNA auxiliary factor 1 like 4
  WD repeat domain 77
  WD repeat domain 83
  WW domain binding protein 11
  zinc finger and BTB domain containing 21
  zinc finger CCCH-type containing 7A
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 638

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.