IVD, isovaleryl-CoA dehydrogenase

IVD, isovaleryl-CoA dehydrogenase

• Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]

• Gene Synonyms (ACAD2, isovaleryl-CoA dehydrogenase, mitochondrial, butyryl-CoA dehydrogenase, epididymis secretory sperm binding protein, isovaleryl Coenzyme A dehydrogenase,)
• NCBI Gene ID: 3712
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0A0MT83
  UNIPROT ID#>>P26440
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

isovaleryl-CoA dehydrogenase interacts with:

• acetyl-CoA acyltransferase 2
  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
  G protein signaling modulator 3
  isovaleryl-CoA dehydrogenase
  killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2
  nudix hydrolase 13
  peptidase, mitochondrial processing subunit alpha
  peptidase, mitochondrial processing subunit beta
  phosphogluconate dehydrogenase
  pleckstrin homology domain containing A4
  PNMA family member 1
  presenilin 1
  serine/threonine kinase 11
  solute carrier family 25 member 41
  telomeric repeat binding factor 2
  testis expressed 101
  thioredoxin reductase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.