NEK2, NIMA related kinase 2

NEK2, NIMA related kinase 2

• This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]

• Gene Synonyms (HsPK21, NEK2A, NLK1, PPP1R111, RP67, serine/threonine-protein kinase Nek2, NIMA (never in mitosis gene a)-related kinase 2, nimA-like protein kinase 1, nimA-related protein kinase 2, protein phosphatase 1, regulatory subunit 111,)
• NCBI Gene ID: 4751
• Species: Homo sapiens (Human)
• UNIPROT ID#>>F6U4U2
  UNIPROT ID#>>P51955
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NIMA related kinase 2 interacts with:

• actin beta like 2
  anaphase promoting complex subunit 1
  anaphase promoting complex subunit 15
  anaphase promoting complex subunit 16
  anaphase promoting complex subunit 2
  anaphase promoting complex subunit 2
  anaphase promoting complex subunit 4
  anaphase promoting complex subunit 5
  anaphase promoting complex subunit 7
  ankyrin repeat and FYVE domain containing 1
  beaded filament structural protein 2
  calmodulin like 5
  CDC16 cell division cycle 16
  CDC23 cell division cycle 23
  cell division cycle 16
  cell division cycle 23
  cell division cycle 26
  centrosomal protein 250
  chromosome 16 open reading frame 87
  cilia and flagella associated protein 97
  coiled-coil domain containing 85A
  coronin 1A
  coronin 1C
  C-type lectin domain family 4 member C
  D-aminoacyl-tRNA deacylase 1
  dipeptidyl peptidase 9
  erythroid differentiation regulatory factor 1
  filaggrin family member 2
  fizzy and cell division cycle 20 related 1
  GIT ArfGAP 1
  H4 clustered histone 1
  heterogeneous nuclear ribonucleoprotein D like
  inner membrane mitochondrial protein
  intraflagellar transport 140
  leucine rich repeat containing 15
  mitogen-activated protein kinase 1
  mitotic arrest deficient 1 like 1
  NDC80 kinetochore complex component
  nicotinamide riboside kinase 2
  NIMA (never in mitosis gene a)-related expressed kinase 2
  NIMA related kinase 11
  NIMA related kinase 2
  nucleophosmin 1
  outer dense fiber of sperm tails 2
  parkin RBR E3 ubiquitin protein ligase
  peroxiredoxin 2
  phosphodiesterase 4D interacting protein
  plakophilin 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 2
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 1 regulatory inhibitor subunit 2
  protein phosphatase 2, regulatory subunit A, alpha
  protein tyrosine phosphatase receptor type D
  ribosomal protein lateral stalk subunit P0
  ring finger protein 41
  RuvB like AAA ATPase 2
  S100 calcium binding protein A7
  semenogelin 1
  semenogelin 2
  serine protease 3
  SET domain containing 1A, histone lysine methyltransferase
  SMAD specific E3 ubiquitin protein ligase 1
  spectrin beta, non-erythrocytic 4
  splicing factor 3b subunit 3
  thyroid hormone receptor associated protein 3
  TRAF family member associated NFKB activator
  transcription factor 25
  tripartite motif containing 21
  tripartite motif containing 27
  tropomodulin 3
  tropomyosin 3
  ubiquitin specific peptidase 7
  valosin containing protein
  vimentin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.