OTX1, orthodenticle homeobox 1

OTX1, orthodenticle homeobox 1

• This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

• Gene Synonyms (homeobox protein OTX1, orthodenticle homolog 1,)
• NCBI Gene ID: 5013
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P32242
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

orthodenticle homeobox 1 interacts with:

• ADAM metallopeptidase domain 12
  ADAMTS like 4
  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
  ankyrin repeat domain 10
  AT-rich interaction domain 5A
  autophagy related 9B
  basic helix-loop-helix family member b9
  cancer/testis antigen 2
  cellular communication network factor 4
  cerebral endothelial cell adhesion molecule
  cholesterol 25-hydroxylase
  chordin
  chordin like 2
  chromosome 11 open reading frame 1
  cysteine rich hydrophobic domain 2
  cysteine rich tail 1
  dpy-30 histone methyltransferase complex regulatory subunit
  EGF containing fibulin extracellular matrix protein 2
  family with sequence similarity 168 member B
  family with sequence similarity 72 member B
  fibulin 5
  four and a half LIM domains 5
  G protein regulated inducer of neurite outgrowth 2
  galectin 13
  H4 clustered histone 1
  integrator complex subunit 11
  kelch like family member 26
  keratin 37
  keratin associated protein 10-1
  keratin associated protein 10-11
  keratin associated protein 10-3
  keratin associated protein 10-5
  keratin associated protein 10-7
  keratin associated protein 10-8
  keratin associated protein 10-9
  keratin associated protein 1-1
  keratin associated protein 11-1
  keratin associated protein 12-1
  keratin associated protein 12-2
  keratin associated protein 12-3
  keratin associated protein 12-4
  keratin associated protein 1-3
  keratin associated protein 13-1
  keratin associated protein 13-2
  keratin associated protein 13-3
  keratin associated protein 1-5
  keratin associated protein 17-1
  keratin associated protein 19-2
  keratin associated protein 19-7
  keratin associated protein 22-1
  keratin associated protein 2-3
  keratin associated protein 2-4
  keratin associated protein 26-1
  keratin associated protein 3-1
  keratin associated protein 3-2
  keratin associated protein 3-3
  keratin associated protein 4-1
  keratin associated protein 4-11
  keratin associated protein 4-12
  keratin associated protein 4-2
  keratin associated protein 4-4
  keratin associated protein 4-5
  keratin associated protein 4-7
  keratin associated protein 5-11
  keratin associated protein 5-3
  keratin associated protein 5-6
  keratin associated protein 6-1
  keratin associated protein 6-2
  keratin associated protein 6-3
  keratin associated protein 7-1
  keratin associated protein 9-2
  keratin associated protein 9-3
  keratin associated protein 9-4
  keratin associated protein 9-8
  keratinocyte proline rich protein
  late cornified envelope 1B
  late cornified envelope 1C
  late cornified envelope 1F
  late cornified envelope 2A
  late cornified envelope 2B
  late cornified envelope 2C
  late cornified envelope 2D
  late cornified envelope 4A
  meiosis 1 associated protein
  migration and invasion inhibitory protein
  NADH:ubiquinone oxidoreductase complex assembly factor 6
  NBPF member 19
  nectin cell adhesion molecule 3
  NHL repeat containing 4
  notch 2 N-terminal like A
  oxoeicosanoid receptor 1
  phospholipase A2 group X
  phospholipid scramblase 2
  pleckstrin homology and RhoGEF domain containing G4
  potassium two pore domain channel subfamily K member 16
  POU class 2 homeobox associating factor 1
  prickle planar cell polarity protein 4
  proline rich 13
  proline rich 22
  proprotein convertase subtilisin/kexin type 5
  regulator of G protein signaling 17
  regulator of G protein signaling 19
  regulator of G protein signaling 20
  reticulon 4 receptor
  Rho guanine nucleotide exchange factor 17
  ring finger protein 144B
  ring finger protein 4
  RNA binding protein, mRNA processing factor
  solute carrier family 15 member 2
  sprouty RTK signaling antagonist 1
  sprouty RTK signaling antagonist 2
  sprouty RTK signaling antagonist 4
  SPRY domain containing 7
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
  tensin 2
  testis expressed 37
  tetraspanin 4
  thyroid hormone receptor interactor 6
  TLE family member 4, transcriptional corepressor
  tripartite motif containing 42
  ubiquitin associated protein 2
  ubiquitin specific peptidase 54
  von Willebrand factor C domain containing 2
  von Willebrand factor C domain containing 2 like
  WW domain containing oxidoreductase
  yippee like 3
  zinc finger and BTB domain containing 42
  zinc finger protein 330
  zinc finger protein 34

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.