POLR2I, RNA polymerase II subunit I

POLR2I, RNA polymerase II subunit I

• This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq, Jul 2008]

• Gene Synonyms (DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerase II 14.5 kDa polypeptide, DNA-directed RNA polymerase II subunit I, RNA polymerase II 14.5 kDa subunit, RNA polymerase II subunit B9, RPB14.5, polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa, polymerase (RNA) II subunit I, RPB9, hRPB14.5,)
• NCBI Gene ID: 5438
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P36954
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RNA polymerase II subunit I interacts with:

• CDKN2A interacting protein
  cleavage and polyadenylation specific factor 6
  COP9 signalosome subunit 5
  copine 2
  cullin 5
  defective in cullin neddylation 1 domain containing 1
  elongin A
  exportin 1
  general transcription factor IIB
  GPN-loop GTPase 3
  H4 clustered histone 1
  mediator complex subunit 10
  mediator complex subunit 19
  mediator complex subunit 21
  mediator complex subunit 26
  mediator complex subunit 29
  PDX1 C-terminal inhibiting factor 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  proteasome 20S subunit beta 9
  RecQ like helicase 5
  regulation of nuclear pre-mRNA domain containing 1B
  regulation of nuclear pre-mRNA domain containing 1B
  RNA guanylyltransferase and 5'-phosphatase
  RNA polymerase I subunit B
  RNA polymerase II subunit M
  RNA polymerase II, I and III subunit K
  RNA polymerase II, I and III subunit L
  SPT5 homolog, DSIF elongation factor subunit
  SRC proto-oncogene, non-receptor tyrosine kinase
  synapse defective Rho GTPase homolog 1
  tubulin folding cofactor D
  ubiquitously expressed prefoldin like chaperone
  valosin containing protein
  WD repeat domain 48
  WW domain containing E3 ubiquitin protein ligase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.