EGLN1, egl-9 family hypoxia inducible factor 1

EGLN1, egl-9 family hypoxia inducible factor 1

• The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009]

• Gene Synonyms (egl nine homolog 1, HIF-prolyl hydroxylase 2, egl nine-like protein 1, hypoxia-inducible factor prolyl hydroxylase 2, prolyl hydroxylase domain-containing protein 2, zinc finger MYND domain-containing protein 6, C1orf12, ECYT3, HALAH, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6,)
• NCBI Gene ID: 54583
• Species: Homo sapiens (Human)
• UNIPROT ID#>>R4SCQ0
  UNIPROT ID#>>Q9GZT9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

egl-9 family hypoxia inducible factor 1 interacts with:

• COBW domain containing 1
  COBW domain containing 2
  EEF1A lysine methyltransferase 1
  egl-9 family hypoxia inducible factor 1
  egl-9 family hypoxia inducible factor 3
  hypoxia inducible factor 3 subunit alpha
  MKS transition zone complex subunit 1
  odd-skipped related transcription factor 1
  pleckstrin homology domain containing A4
  ret finger protein like 4B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.