PRCC, proline rich mitotic checkpoint control factor

PRCC, proline rich mitotic checkpoint control factor

• This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]

• Gene Synonyms (proline-rich protein PRCC, PRCC, proline rich mitotic checkpoint control factor, papillary renal cell carcinoma (translocation-associated), papillary renal cell carcinoma translocation-associated gene protein, RCCP1, TPRC,)
• NCBI Gene ID: 5546
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92733
  UNIPROT ID#>>A0A0S2Z470
  UNIPROT ID#>>Q96FT4
  UNIPROT ID#>>A0A0S2Z456
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proline rich mitotic checkpoint control factor interacts with:

• BCAS2 pre-mRNA processing factor
  breast carcinoma amplified sequence 2
  chromosome 19 open reading frame 57
  coactivator associated arginine methyltransferase 1
  COPI coat complex subunit zeta 1
  crooked neck pre-mRNA splicing factor 1
  crooked neck pre-mRNA splicing factor 1
  cysteine and histidine rich domain containing 1
  DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
  exportin 1
  Fas associated factor 1
  FKBP prolyl isomerase 9
  golgi reassembly stacking protein 2
  homer scaffold protein 3
  interacts with SUPT6H, CTD assembly factor 1
  LDL receptor related protein 8
  LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  mitotic arrest deficient 2 like 2
  nucleic acid binding protein 2
  peptidylprolyl isomerase like 2
  Pim-2 proto-oncogene, serine/threonine kinase
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 19
  RNA binding motif protein 10
  SAP domain containing ribonucleoprotein
  SCY1 like pseudokinase 2
  septin 11
  serine and arginine rich splicing factor 2
  SH3 domain containing GRB2 like, endophilin B1
  sortilin 1
  splicing factor 3a subunit 2
  SUB1 regulator of transcription
  superoxide dismutase 1
  target of EGR1, exonuclease
  transketolase like 2
  tripartite motif containing 25
  tumor protein p53 binding protein 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  WD repeat containing, antisense to TP73
  zinc finger protein 281

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.