PTPN13, protein tyrosine phosphatase non-receptor type 13

PTPN13, protein tyrosine phosphatase non-receptor type 13

• The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]

• Gene Synonyms (tyrosine-protein phosphatase non-receptor type 13, fas-associated protein-tyrosine phosphatase 1, hPTPE1, protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase), protein-tyrosine phosphatase 1E, protein-tyrosine phosphatase PTPL1, FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E,)
• NCBI Gene ID: 5783
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q12923
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein tyrosine phosphatase non-receptor type 13 interacts with:

• brain expressed X-linked 3
  bromodomain containing 7
  chibby family member 1, beta catenin antagonist
  cingulin
  CTD phosphatase subunit 1
  DENN domain containing 1A
  DENN domain containing 4C
  egl-9 family hypoxia inducible factor 3
  endosome associated trafficking regulator 1
  eukaryotic translation initiation factor 4E family member 2
  Fas associated via death domain
  F-box and leucine rich repeat protein 2
  F-box and WD repeat domain containing 11
  GIT ArfGAP 1
  GRB10 interacting GYF protein 1
  GRB10 interacting GYF protein 2
  hes related family bHLH transcription factor with YRPW motif 1
  inositol polyphosphate-5-phosphatase E
  kinase suppressor of ras 1
  kinesin family member 13B
  large tumor suppressor kinase 1
  large tumor suppressor kinase 2
  leucine rich repeat and fibronectin type III domain containing 1
  lipin 3
  microtubule associated serine/threonine kinase 3
  mindbomb E3 ubiquitin protein ligase 1
  ninein like
  nuclear receptor binding SET domain protein 2
  PDZ and LIM domain 4
  PDZ and LIM domain 4
  pleckstrin homology domain containing A1
  pleckstrin homology domain containing A2
  pleckstrin homology domain containing A4
  potassium channel tetramerization domain containing 3
  protein phosphatase, Mg2+/Mn2+ dependent 1H
  Ral GEF with PH domain and SH3 binding motif 2
  Rap guanine nucleotide exchange factor 2
  Rap guanine nucleotide exchange factor 6
  Ras association domain family member 10
  regulator of G protein signaling 2
  Rho GTPase activating protein 29
  rhotekin
  SH3 and PX domains 2A
  SH3 domain containing ring finger 3
  signal induced proliferation associated 1 like 1
  SLIT-ROBO Rho GTPase activating protein 2
  syntaxin binding protein 4
  tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
  thyroid hormone receptor interactor 6
  TNFAIP3 interacting protein 2
  transmembrane protein 17
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  UFM1 specific ligase 1
  vir like m6A methyltransferase associated
  zinc finger and BTB domain containing 21

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.