RRM1, ribonucleotide reductase catalytic subunit M1

RRM1, ribonucleotide reductase catalytic subunit M1

• This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

• Gene Synonyms (ribonucleoside-diphosphate reductase large subunit, ribonucleoside-diphosphate reductase subunit M1, ribonucleotide reductase M1 polypeptide, ribonucleotide reductase, R1 subunit, R1, RIR1, RR1,)
• NCBI Gene ID: 6240
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4E0I8
  UNIPROT ID#>>B4DXD1
  UNIPROT ID#>>E9PL69
  UNIPROT ID#>>P23921
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ribonucleotide reductase catalytic subunit M1 interacts with:

• AAR2 splicing factor
  ADP ribosylation factor like GTPase 5B
  CDKN2A interacting protein
  cell division cycle associated 8
  centrosomal protein 152
  COP9 signalosome subunit 5
  DnaJ heat shock protein family (Hsp40) member B11
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  F-box protein 6
  glutaredoxin 3
  growth factor independent 1B transcriptional repressor
  HEXIM P-TEFb complex subunit 1
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leucine rich repeat kinase 2
  ligand dependent nuclear receptor interacting factor 1
  lysine acetyltransferase 5
  MDM2 binding protein
  neutrophil cytosolic factor 1
  N-sulfoglucosamine sulfohydrolase
  OFD1 centriole and centriolar satellite protein
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  ribonuclease H2 subunit B
  ribonucleotide reductase catalytic subunit M1
  ribonucleotide reductase regulatory subunit M2
  ribonucleotide reductase regulatory TP53 inducible subunit M2B
  ribosomal protein L35
  ring finger protein 126
  SPOUT domain containing methyltransferase 1
  succinate-CoA ligase ADP-forming subunit beta
  SUMO specific peptidase 3
  transmembrane protein 177
  transmembrane protein 184A
  tripartite motif containing 33
  tripartite motif containing 69
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin protein ligase E3C
  zinc finger protein 655

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.