MOGS, mannosyl-oligosaccharide glucosidase

MOGS, mannosyl-oligosaccharide glucosidase

• This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

• Gene Synonyms (mannosyl-oligosaccharide glucosidase, epididymis secretory sperm binding protein, glucosidase I, processing A-glucosidase I, CDG2B, CWH41, DER7, GCS1,)
• NCBI Gene ID: 7841
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13724
  UNIPROT ID#>>Q58F09
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mannosyl-oligosaccharide glucosidase interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  aurora kinase B
  autophagy related 16 like 1
  bromodomain adjacent to zinc finger domain 1A
  bromodomain containing 7
  calreticulin 3
  centrosomal protein 250
  centrosomal protein 57
  centrosomal protein 76
  clusterin associated protein 1
  coactivator associated arginine methyltransferase 1
  cullin associated and neddylation dissociated 1
  DAZ associated protein 1
  DDB1 and CUL4 associated factor 7
  developmental pluripotency-associated 3
  DNA polymerase epsilon 3, accessory subunit
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  ER degradation enhancing alpha-mannosidase like protein 3
  EvC ciliary complex subunit 2
  glucosidase II alpha subunit
  H3 clustered histone 1
  H4 clustered histone 1
  HAUS augmin like complex subunit 2
  heterogeneous nuclear ribonucleoprotein R
  histone deacetylase 8
  insulin like growth factor 2 mRNA binding protein 1
  katanin p60 (ATPase-containing) subunit A1
  limb development membrane protein 1 like
  mannosidase alpha class 1B member 1
  mediator complex subunit 4
  MORC family CW-type zinc finger 3
  neurochondrin
  nucleoporin 62
  RAB1B, member RAS oncogene family
  RecQ like helicase 4
  ring finger and CCCH-type domains 1
  ring finger protein 123
  RPTOR independent companion of MTOR complex 2
  SEC23 interacting protein
  SEC31 homolog A, COPII coat complex component
  secretion associated Ras related GTPase 1A
  sequestosome 1
  smoothened, frizzled class receptor
  solute carrier family 30 member 5
  solute carrier family 33 member 1
  solute carrier family 39 member 7
  SUMO specific peptidase 3
  tectonic family member 1
  trafficking protein particle complex 11
  trafficking protein particle complex 12
  trafficking protein particle complex 2 like
  trans-2,3-enoyl-CoA reductase
  translocase of outer mitochondrial membrane 40
  translocase of outer mitochondrial membrane 5
  ubiquilin 2
  ubiquitin like 4A
  ubiquitin like modifier activating enzyme 5
  ubiquitin specific peptidase 11
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.