TCL1A, TCL1 family AKT coactivator A

TCL1A, TCL1 family AKT coactivator A

• Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

• Gene Synonyms (T-cell leukemia/lymphoma protein 1A, T cell leukemia/lymphoma 1A, T-cell lymphoma-1, oncogene TCL-1, oncogene TCL1, protein p14 TCL1, TCL1,)
• NCBI Gene ID: 8115
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R6G5
  UNIPROT ID#>>P56279
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TCL1 family AKT coactivator A interacts with:

• AKT serine/threonine kinase 3
  calcium binding and coiled-coil domain 2
  calcium dependent secretion activator
  caspase 8 associated protein 2
  caspase recruitment domain family member 9
  centrosomal protein 55
  coiled-coil domain containing 13
  DNA damage inducible transcript 4 like
  flagellum associated containing coiled-coil domains 1
  H2A.W histone
  inhibitor of CDK, cyclin A1 interacting protein 1
  ligand of numb-protein X 1
  ligand of numb-protein X 2
  LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
  NFKB inhibitor delta
  NGG1 interacting factor 3 like 1
  N-terminal glutamine amidase 1
  phosphoribosyl transferase domain containing 1
  protein phosphatase 1 regulatory subunit 13B
  tankyrase
  Tax1 binding protein 1
  taxilin alpha
  taxilin beta
  TCL1 family AKT coactivator A
  TEPSIN adaptor related protein complex 4 accessory protein
  tetratricopeptide repeat domain 33
  tRNA methyltransferase 61A
  WD repeat domain 47

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.