EIF4G3, eukaryotic translation initiation factor 4 gamma 3

EIF4G3, eukaryotic translation initiation factor 4 gamma 3

• The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]

• Gene Synonyms (eukaryotic translation initiation factor 4 gamma 3, eIF-4-gamma 3, eIF-4-gamma II, eIF-4G 3, eIF4G 3, eIF4GII,)
• NCBI Gene ID: 8672
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q59GJ0
  UNIPROT ID#>>A0A0A0MSA7
  UNIPROT ID#>>O43432
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

eukaryotic translation initiation factor 4 gamma 3 interacts with:

• catechol-O-methyltransferase domain containing 1
  CTR9 homolog, Paf1/RNA polymerase II complex component
  eukaryotic translation initiation factor 2B subunit epsilon
  glutamate rich WD repeat containing 1
  hydroxyacid oxidase 2
  kaptin, actin binding protein
  leucine rich repeat containing G protein-coupled receptor 4
  limb development membrane protein 1 like
  N-terminal glutamine amidase 1
  nuclear factor of activated T cells 2 interacting protein
  pleckstrin homology domain containing A4
  PNKD metallo-beta-lactamase domain containing
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  pseudouridine synthase 7
  quinolinate phosphoribosyltransferase
  RNA binding fox-1 homolog 2
  SIGLEC family like 1
  sirtuin 7
  TAR DNA binding protein
  terminal nucleotidyltransferase 5A
  tripartite motif containing 28
  ubiquitin specific peptidase 10
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.