P4HA2, prolyl 4-hydroxylase subunit alpha 2

P4HA2, prolyl 4-hydroxylase subunit alpha 2

• This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

• Gene Synonyms (prolyl 4-hydroxylase subunit alpha-2, 4-PH alpha 2, C-P4Halpha(II), collagen prolyl 4-hydroxylase alpha(II), procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II, procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2, prolyl 4-hydroxylase, alpha polypeptide II, MYP25,)
• NCBI Gene ID: 8974
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O15460
  UNIPROT ID#>>Q05DA4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

prolyl 4-hydroxylase subunit alpha 2 interacts with:

• autophagy related 4D cysteine peptidase
  BAG cochaperone 3
  cAMP responsive element binding protein 3
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 7
  chromosome 15 open reading frame 39
  chromosome transmission fidelity factor 18
  cleavage and polyadenylation specific factor 3
  cleavage and polyadenylation specific factor 4
  coiled-coil domain containing 85C
  cytokine dependent hematopoietic cell linker
  cytosolic thiouridylase subunit 1
  DISC1 scaffold protein
  DNA replication and sister chromatid cohesion 1
  DnaJ heat shock protein family (Hsp40) member B5
  eukaryotic translation initiation factor 4E family member 2
  FA core complex associated protein 100
  factor interacting with PAPOLA and CPSF1
  family with sequence similarity 83 member H
  G2 and S-phase expressed 1
  intermediate filament family orphan 1
  IQ motif and Sec7 domain ArfGEF 1
  KIAA1671
  kinesin family member 18B
  kinesin family member 7
  kinesin family member 7
  MAP7 domain containing 1
  MAP7 domain containing 2
  maternal embryonic leucine zipper kinase
  minichromosome maintenance 8 homologous recombination repair factor
  myosin VC
  NIMA related kinase 7
  prolyl 4-hydroxylase subunit alpha 2
  protein kinase N3
  RecQ like helicase 4
  ribonucleoprotein, PTB binding 1
  RNA binding motif protein 8a
  RNA polymerase III subunit B
  RPTOR independent companion of MTOR complex 2
  salvador family WW domain containing protein 1
  SCY1 like pseudokinase 1
  SEC16 homolog A, endoplasmic reticulum export factor
  SH3KBP1 binding protein 1
  SMG8 nonsense mediated mRNA decay factor
  STIP1 homology and U-box containing protein 1
  synaptojanin 2 binding protein
  TATA-box binding protein associated factor, RNA polymerase I subunit C
  tensin 4
  tetratricopeptide repeat domain 28
  tigger transposable element derived 5
  transport and golgi organization 6 homolog
  tripartite motif containing 32
  tripartite motif containing 65
  tRNA methyltransferase 1
  tRNA methyltransferase 44 homolog
  TSC22 domain family member 4
  TSPY like 4
  TSR3 ribosome maturation factor
  ubiquitin specific peptidase 54
  UTP14A small subunit processome component
  WD repeat domain 33
  WD repeat domain 62
  WW domain binding protein 11

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.