RNF7, ring finger protein 7

RNF7, ring finger protein 7

• The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

• Gene Synonyms (RING-box protein 2, CKII beta-binding protein 1, regulator of cullins 2, sensitive to apoptosis gene protein, sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2, zinc RING finger protein SAG, CKBBP1, ROC2, SAG, rbx2,)
• NCBI Gene ID: 9616
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UBF6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring finger protein 7 interacts with:

• ankyrin repeat and SOCS box containing 1
  ankyrin repeat and SOCS box containing 10
  ankyrin repeat and SOCS box containing 12
  ankyrin repeat and SOCS box containing 13
  ankyrin repeat and SOCS box containing 2
  ankyrin repeat and SOCS box containing 4
  ankyrin repeat and SOCS box containing 6
  ankyrin repeat and SOCS box containing 7
  apolipoprotein B mRNA editing enzyme catalytic subunit 3F
  apolipoprotein B mRNA editing enzyme catalytic subunit 3G
  caspase recruitment domain family member 14
  checkpoint with forkhead and ring finger domains
  cytochrome c, somatic
  defective in cullin neddylation 1 domain containing 2
  defective in cullin neddylation 1 domain containing 3
  defective in cullin neddylation 1 domain containing 4
  defective in cullin neddylation 1 domain containing 5
  erbb2 interacting protein
  glomulin, FKBP associated protein
  integral membrane protein 2C
  leucine rich repeat containing 41
  NEDD4 like E3 ubiquitin protein ligase
  phospholipase A2 group XV
  pleckstrin homology domain containing A4
  RAB40C, member RAS oncogene family
  ring finger protein 7
  splA/ryanodine receptor domain and SOCS box containing 1
  splA/ryanodine receptor domain and SOCS box containing 2
  splA/ryanodine receptor domain and SOCS box containing 4
  suppressor of cytokine signaling 1
  tripartite motif containing 46
  tripartite motif containing 8
  ubiquitin conjugating enzyme E2 C
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin conjugating enzyme E2 F (putative)
  ubiquitin conjugating enzyme E2 Q1
  ubiquitin conjugating enzyme E2 S
  WD repeat and SOCS box-containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.