MVP, major vault protein

MVP, major vault protein

• This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

• Gene Synonyms (major vault protein, lung resistance-related protein, testicular secretory protein Li 30, LRP, VAULT1,)
• NCBI Gene ID: 9961
• Species: Homo sapiens (Human)
• UNIPROT ID#>>X5D7K9
  UNIPROT ID#>>Q14764
  UNIPROT ID#>>X5DNU0
  UNIPROT ID#>>X5D2M8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

major vault protein interacts with:

• actin, beta
  ADAMTS like 4
  BTG3 associated nuclear protein
  calcium binding and coiled-coil domain 2
  cap methyltransferase 1
  CD276 molecule
  centrosomal protein 78
  charged multivesicular body protein 4B
  charged multivesicular body protein 4B
  chromatin assembly factor 1, subunit A (p150)
  chromosome 1 open reading frame 94
  COP1 E3 ubiquitin ligase
  cyclic GMP-AMP synthase
  cytoskeleton associated protein 4
  DEAD-box helicase 19B
  deltex E3 ubiquitin ligase 2
  DISC1 scaffold protein
  F-box and WD-40 domain protein 11
  fibronectin type III domain containing 3B
  G2 and S-phase expressed 1
  golgi associated PDZ and coiled-coil motif containing
  interactor of HORMAD1 1
  lectin, galactoside-binding, soluble, 3 binding protein
  major vault protein
  microtubule associated protein 1 light chain 3 alpha
  microtubule-associated protein 9
  midline 2
  myocardin related transcription factor A
  nicotinamide nucleotide transhydrogenase
  notch 2 N-terminal like A
  N-terminal glutamine amidase 1
  PIH1 domain containing 2
  potassium channel tetramerization domain containing 9
  proteasome 26S subunit, non-ATPase 14
  protection of telomeres 1
  protein tyrosine phosphatase, non-receptor type 2
  RAB3A interacting protein
  REST corepressor 3
  Rhox homeobox family member 2
  RIMS binding protein 3
  ring finger protein 111
  RNA binding protein, mRNA processing factor
  SERTA domain containing 1
  sirtuin 7
  SNW domain containing 1
  stabilizer of axonemal microtubules 1
  STN1 subunit of CST complex
  terminal nucleotidyltransferase 5C
  toll interacting protein
  tripartite motif containing 42
  tubulin, epsilon 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin domain containing 2
  VAC14 component of PIKFYVE complex
  vesicle amine transport 1
  WW domain containing E3 ubiquitin protein ligase 2
  zinc finger and BTB domain containing 32
  zinc finger MIZ-type containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.