HDAC6, histone deacetylase 6

HDAC6, histone deacetylase 6

• Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

• Gene Synonyms (histone deacetylase 6, protein phosphatase 1, regulatory subunit 90, tubulin-lysine deacetylase HDAC6, CPBHM, HD6, JM21, PPP1R90,)
• NCBI Gene ID: 10013
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UBN7
  UNIPROT ID#>>A0A024QZ26
  UNIPROT ID#>>B4DZH6
  UNIPROT ID#>>Q9BRX7
  UNIPROT ID#>>Q9NSW6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

histone deacetylase 6 interacts with:

• AAR2 splicing factor
  actin related protein 1A
  activator of basal transcription 1
  apolipoprotein B mRNA editing enzyme catalytic subunit 3G
  apoptotic chromatin condensation inducer 1
  ATPase cation transporting 13A2
  ATPase family AAA domain containing 3A
  BAF chromatin remodeling complex subunit BCL11B
  Bardet-Biedl syndrome 10
  BCL6 corepressor
  BRMS1 transcriptional repressor and anoikis regulator
  BTG3 associated nuclear protein
  centlein
  centromere protein J
  centrosomal protein 70
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  cleavage and polyadenylation specific factor 1
  CTTNBP2 N-terminal like
  DEAD-box helicase 19A
  DEAD-box helicase 41
  dedicator of cytokinesis 5
  DExD/H-box helicase 58
  diaphanous related formin 3
  DNA polymerase alpha 2, accessory subunit
  DNA polymerase delta interacting protein 2
  DnaJ heat shock protein family (Hsp40) member B6
  DnaJ heat shock protein family (Hsp40) member B8
  endoplasmic reticulum aminopeptidase 1
  exportin for tRNA
  F-box protein 11
  FKBP prolyl isomerase 15
  forkhead box R1
  G3BP stress granule assembly factor 1
  gem nuclear organelle associated protein 5
  glucosidase II alpha subunit
  glyoxalase domain containing 5
  H4 histone 16
  heterogeneous nuclear ribonucleoprotein R
  histone deacetylase 11
  histone deacetylase 6
  histone deacetylase 6
  HIV-1 Tat interactive protein 2
  HIV-1 Tat specific factor 1
  importin 7
  integrin alpha FG-GAP repeat containing 1
  itchy E3 ubiquitin protein ligase
  Jun dimerization protein 2
  KH RNA binding domain containing, signal transduction associated 1
  kinase suppressor of ras 1
  leucine rich repeat kinase 2
  ligand dependent nuclear receptor corepressor
  lipin 3
  lysine acetyltransferase 5
  lysine demethylase 1A
  lysine methyltransferase 5A
  MAGE family member F1
  MAP7 domain containing 3
  microtubule associated protein RP/EB family member 1
  migration and invasion inhibitory protein
  mitochondrial ribosomal protein S36
  MMS19 homolog, cytosolic iron-sulfur assembly component
  myocyte enhancer factor 2B
  NAC alpha domain containing
  neuron navigator 2
  NLR family pyrin domain containing 3
  nuclear RNA export factor 1
  nucleoporin 50
  OTU deubiquitinase with linear linkage specificity
  pelota mRNA surveillance and ribosome rescue factor
  peroxiredoxin 4
  phosphoglycerate dehydrogenase
  PIH1 domain containing 1
  poly(U) binding splicing factor 60
  polybromo 1
  pre-mRNA processing factor 8
  prohibitin 2
  protein disulfide isomerase family A member 6
  protein kinase N3
  PTOV1 extended AT-hook containing adaptor protein
  RAD50 double strand break repair protein
  RAN binding protein 9
  RAN binding protein 9
  ring finger protein 31
  RNA polymerase I subunit B
  RuvB like AAA ATPase 2
  salvador family WW domain containing protein 1
  serine/arginine repetitive matrix 2
  sirtuin 2
  SLX1 homolog A, structure-specific endonuclease subunit
  splicing factor 3a subunit 1
  STIP1 homology and U-box containing protein 1
  TAR DNA binding protein
  TBC1 domain family member 16
  translocase of inner mitochondrial membrane 50
  transmembrane protein 161A
  tripartite motif containing 50
  tubulin alpha 1b
  tubulin alpha 1c
  tubulin alpha 8
  tubulin beta 2B class IIb
  tubulin beta 3 class III
  tubulin beta 4A class IVa
  tubulin beta 4B class IVb
  tubulin beta class I
  tubulin polymerization promoting protein
  ubiquitin D
  ubiquitin like 7
  ubiquitin specific peptidase 47
  UTP15 small subunit processome component
  UTP4 small subunit processome component
  vir like m6A methyltransferase associated
  vitamin K epoxide reductase complex subunit 1
  zinc finger MYM-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.