RPS6KB1, ribosomal protein S6 kinase B1

RPS6KB1, ribosomal protein S6 kinase B1

• This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]

• Gene Synonyms (ribosomal protein S6 kinase beta-1, p70 S6 kinase, alpha, ribosomal protein S6 kinase I, ribosomal protein S6 kinase, 70kDa, polypeptide 1, serine/threonine kinase 14 alpha, serine/threonine-protein kinase 14A, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha,)
• NCBI Gene ID: 6198
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P23443
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ribosomal protein S6 kinase B1 interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  BICD cargo adaptor 2
  Coenzyme A synthase
  C-type lectin domain family 3 member B
  DEP domain containing MTOR interacting protein
  developmental pluripotency associated 4
  DNA polymerase delta interacting protein 3
  dynein cytoplasmic 1 light intermediate chain 1
  eukaryotic elongation factor 2 kinase
  eukaryotic translation initiation factor 3 subunit B
  eukaryotic translation initiation factor 3 subunit C
  eukaryotic translation initiation factor 3 subunit F
  eukaryotic translation initiation factor 3 subunit H
  exportin 1
  exportin 1
  F-box protein 7
  insulin receptor substrate 2
  lysine acetyltransferase 2B
  MAPK associated protein 1
  NIMA related kinase 6
  nuclear receptor subfamily 1 group I member 2
  protein phosphatase 1 regulatory subunit 9A
  protein phosphatase 1 regulatory subunit 9B
  regulatory associated protein of MTOR complex 1
  ribonucleotide reductase regulatory subunit M2
  ribosomal protein S6 kinase B1
  ring-box 1
  RPTOR independent companion of MTOR complex 2
  sequestosome 1
  serine/threonine kinase 11
  signal transducer and activator of transcription 1
  spleen associated tyrosine kinase
  SRC proto-oncogene, non-receptor tyrosine kinase
  TANK binding kinase 1
  telomerase reverse transcriptase
  TNF receptor associated factor 4
  tribbles pseudokinase 2
  tripartite motif containing 25
  ubiquitin like 4A
  ubiquitin specific peptidase 11
  URI1 prefoldin like chaperone
  von Hippel-Lindau tumor suppressor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.