SF1, splicing factor 1

SF1, splicing factor 1

• This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

• Gene Synonyms (splicing factor 1, mammalian branch point-binding protein, transcription factor ZFM1, zinc finger gene in MEN1 locus, zinc finger protein 162, BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162,)
• NCBI Gene ID: 7536
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R572
  UNIPROT ID#>>A0A024R588
  UNIPROT ID#>>Q15637
  UNIPROT ID#>>B4DX42
  UNIPROT ID#>>A0A024R5D9
  UNIPROT ID#>>A0A024R566
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

splicing factor 1 interacts with:

• angiomotin
  BCAS2 pre-mRNA processing factor
  bromodomain containing 7
  calcium binding protein 39
  calpain 13
  CDKN2A interacting protein
  charged multivesicular body protein 4C
  coiled-coil domain containing 25
  coiled-coil domain containing 8
  cullin 1
  cullin 3
  cullin 4B
  cullin 7
  cytosolic iron-sulfur assembly component 1
  DEAD-box helicase 17
  developmental pluripotency-associated 3
  DISC1 scaffold protein
  dynein cytoplasmic 1 light intermediate chain 1
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  ER membrane protein complex subunit 2
  exportin 7
  family with sequence similarity 168 member A
  Fas associated factor 1
  growth arrest specific 7
  H4 clustered histone 1
  heat shock protein family H (Hsp110) member 1
  heterogeneous nuclear ribonucleoprotein U like 1
  HEXIM P-TEFb complex subunit 1
  HIRA interacting protein 3
  histone deacetylase 4
  histone deacetylase 5
  HSPA (Hsp70) binding protein 1
  hydroxyacid oxidase 2
  hydroxysteroid dehydrogenase like 2
  integrin beta 1 (fibronectin receptor beta)
  interferon induced transmembrane protein 3
  intersectin 2
  itchy E3 ubiquitin protein ligase
  jun B proto-oncogene
  keratin associated protein 26-1
  kinesin family member 19A
  kinesin light chain 3
  leucine rich repeat kinase 2
  makorin ring finger protein 3
  methyltransferase like 22
  M-phase specific PLK1 interacting protein
  N(alpha)-acetyltransferase 11, NatA catalytic subunit
  N-acetylglucosamine kinase
  NCK adaptor protein 2
  nicotinamide nucleotide transhydrogenase
  nuclear receptor coactivator 1
  nuclear receptor corepressor 2
  obscurin like cytoskeletal adaptor 1
  osteoclast stimulating factor 1
  par-6 family cell polarity regulator beta
  PDZ and LIM domain 5
  peptidylprolyl isomerase E
  phenylalanyl-tRNA synthetase subunit beta
  phospholipase A2 activating protein
  pleckstrin homology domain containing A4
  poly(U) binding splicing factor 60
  potassium channel tetramerization domain containing 10
  PPARG coactivator 1 alpha
  prefoldin 2
  pre-mRNA processing factor 40 homolog A
  prolyl 4-hydroxylase subunit alpha 3
  protein kinase C, zeta
  protein phosphatase 2, regulatory subunit A, alpha
  RAN binding protein 3
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 123
  ring finger protein 41
  RNA binding motif protein 10
  RNA binding motif protein 17
  RNA binding motif protein 7
  RNA binding protein, mRNA processing factor
  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
  SBDS ribosome maturation factor
  Sec23 homolog A, COPII coat complex component
  septin 11
  shugoshin 2A
  SIN3 transcription regulator family member A
  sortilin related VPS10 domain containing receptor 3
  splicing factor 1
  splicing factor 3a subunit 1
  splicing factor 3a subunit 2
  splicing factor 3b subunit 1
  splicing factor 3b subunit 4
  SRP receptor subunit beta
  SUZ12 polycomb repressive complex 2 subunit
  TATA-box binding protein associated factor 15
  testin LIM domain protein
  thioredoxin like 4B
  trafficking protein particle complex 8
  transcription elongation regulator 1
  translocase of outer mitochondrial membrane 40
  transmembrane p24 trafficking protein 4
  transportin 2
  tripartite motif containing 69
  tubulin, alpha 3A
  tubulin, gamma 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin like 5
  WD repeat domain 77
  WD repeat domain 83
  WW domain binding protein 4
  WW domain containing E3 ubiquitin protein ligase 2
  ZFP41 zinc finger protein
  zinc finger CCCH-type containing 11A
  zinc finger RNA binding protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.