MAPKAPK5, MAPK activated protein kinase 5

MAPKAPK5, MAPK activated protein kinase 5

• The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]

• Gene Synonyms (MAP kinase-activated protein kinase 5, MAPKAP kinase 5, MAPKAPK-5, mitogen-activated protein kinase-activated protein kinase 5, p38-regulated/activated protein kinase, MAPKAP-K5, MK-5, MK5, PRAK,)
• NCBI Gene ID: 8550
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IW41
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MAPK activated protein kinase 5 interacts with:

• cell division cycle associated 8
  eukaryotic elongation factor 2 kinase
  lipolysis stimulated lipoprotein receptor
  MAPK activated protein kinase 2
  MAPK activated protein kinase 5
  Parkinsonism associated deglycase
  serine/threonine kinase 40
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  zinc finger protein 576

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.