STIP1, stress induced phosphoprotein 1

STIP1, stress induced phosphoprotein 1

• STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]

• Gene Synonyms (HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L, stress-induced-phosphoprotein 1, Hsp70/Hsp90-organizing protein, NY-REN-11 antigen, epididymis secretory sperm binding protein Li 94n, hsc70/Hsp90-organizing protein, renal carcinoma antigen NY-REN-11, transformation-sensitive protein IEF SSP 3521,)
• NCBI Gene ID: 10963
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P31948
  UNIPROT ID#>>V9HW72
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

stress induced phosphoprotein 1 interacts with:

• AAR2 splicing factor
  abhydrolase domain containing 15
  ACD shelterin complex subunit and telomerase recruitment factor
  ADP ribosylation factor interacting protein 1
  AHNAK nucleoprotein
  aldo-keto reductase family 1 member B15
  autophagy and beclin 1 regulator 1
  BCL2-associated athanogene 2
  cell division cycle 37 like 1
  cell division cycle 37, HSP90 cochaperone
  centrin 2
  cilia and flagella associated protein 52
  coiled-coil domain containing 117
  coiled-coil domain containing 14
  coiled-coil domain containing 8
  COP9 signalosome subunit 4
  DEAD-box helicase 59
  DExD/H-box helicase 60
  DnaJ heat shock protein family (Hsp40) member B4
  dual specificity phosphatase 13
  dynein axonemal intermediate chain 2
  EEF1A lysine methyltransferase 3
  egl-9 family hypoxia inducible factor 3
  EvC ciliary complex subunit 2
  fibrillarin
  folliculin
  folliculin interacting protein 1
  folliculin interacting protein 2
  GrpE like 1, mitochondrial
  heat shock protein family A (Hsp70) member 14
  huntingtin
  hydroxyacid oxidase 2
  kelch like family member 34
  kinase suppressor of ras 1
  leucine rich repeat kinase 2
  methyltransferase like 3
  microtubule associated protein 1S
  mitochondrial carrier 2
  mitogen-activated protein kinase 13
  musashi RNA binding protein 2
  myotubularin related protein 14
  myotubularin related protein 8
  NADPH oxidase 5
  nephrocystin 4
  NIMA related kinase 8
  NLR family pyrin domain containing 5
  NME1-NME2 readthrough
  parkin coregulated
  patatin like phospholipase domain containing 5
  phosphoglycerate dehydrogenase
  phosphoglycolate phosphatase
  PIH1 domain containing 1
  potassium channel tetramerization domain containing 10
  protection of telomeres 1
  protein phosphatase, Mg2+/Mn2+ dependent 1M
  protein tyrosine phosphatase non-receptor type 18
  protein tyrosine phosphatase non-receptor type 23
  PTEN induced kinase 1
  receptor interacting serine/threonine kinase 3
  receptor interacting serine/threonine kinase 4
  ring finger protein 123
  SAMM50 sorting and assembly machinery component
  serine/threonine/tyrosine interacting like 1
  slingshot protein phosphatase 3
  small ubiquitin like modifier 4
  tensin 3
  TNFAIP3 interacting protein 2
  transgelin 3
  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
  tripartite motif family like 2
  tubulin alpha 1c
  tubulin, epsilon 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin protein ligase E3D
  ubiquitin specific peptidase 49
  vir like m6A methyltransferase associated
  WD repeat containing, antisense to TP73
  WW domain containing oxidoreductase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.