CDC37, cell division cycle 37, HSP90 cochaperone

CDC37, cell division cycle 37, HSP90 cochaperone

• The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]

• Gene Synonyms (hsp90 co-chaperone Cdc37, CDC37 (cell division cycle 37, S. cerevisiae, homolog), CDC37 cell division cycle 37 homolog, cell division cycle 37 homolog, hsp90 chaperone protein kinase-targeting subunit, P50CDC37,)
• NCBI Gene ID: 11140
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R7B7
  UNIPROT ID#>>Q16543
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cell division cycle 37, HSP90 cochaperone interacts with:

• 5'-nucleotidase, cytosolic IA
  agrin
  angiomotin like 2
  autophagy related 101
  basic helix-loop-helix family member b9
  BEN domain containing 7
  BTB domain containing 10
  BTB domain containing 3
  cancer/testis antigen 1A
  cancer/testis antigen family 45 member A1
  caspase recruitment domain family member 10
  caspase recruitment domain family member 9
  caveolae associated protein 1
  cell division cycle 37 like 1
  cell division cycle 37, HSP90 cochaperone
  cell division cycle associated 5
  centrosomal protein 55
  centrosomal protein 70
  chibby family member 2
  chromosome 19 open reading frame 44
  ciliogenesis and planar polarity effector 2
  coiled-coil alpha-helical rod protein 1
  coiled-coil and C2 domain containing 1A
  coiled-coil domain containing 138
  coiled-coil domain containing 152
  coiled-coil domain containing 91
  COPI coat complex subunit epsilon
  coronin, actin binding protein 1C
  cutC copper transporter
  cyclin dependent kinase 11A
  cyclin dependent kinase 15
  cysteine and histidine rich domain containing 1
  DISC1 scaffold protein
  ECSIT signaling integrator
  egl-9 family hypoxia inducible factor 3
  ER degradation enhancing alpha-mannosidase like protein 3
  eukaryotic translation initiation factor 2 alpha kinase 1
  EvC ciliary complex subunit 2
  exosome component 1
  family with sequence similarity 118 member A
  family with sequence similarity 9 member B
  F-box and leucine rich repeat protein 12
  F-box protein 6
  fetal and adult testis expressed 1
  FKBP prolyl isomerase like
  folliculin
  folliculin interacting protein 1
  folliculin interacting protein 2
  FtsJ RNA 2'-O-methyltransferase 1
  germ cell-less 1, spermatogenesis associated
  glomulin, FKBP associated protein
  golgin A6 family like 9
  GRAM domain containing 2B
  GRIP1 associated protein 1
  heterogeneous nuclear ribonucleoprotein A3
  hypoxia inducible factor 1 subunit alpha inhibitor
  IKAROS family zinc finger 3
  interferon induced protein with tetratricopeptide repeats 5
  katanin regulatory subunit B1 like 1
  kelch like family member 2
  keratin 76
  kinase suppressor of ras 1
  L3MBTL histone methyl-lysine binding protein 1
  lamin B2
  leucine rich repeat kinase 1
  leucine rich repeat kinase 2
  leucine zipper tumor suppressor 1
  LUC7 like 2, pre-mRNA splicing factor
  lysyl oxidase like 4
  mirror-image polydactyly 1
  mitochondrial ribosomal protein L9
  mitotic spindle organizing protein 2B
  myosin light chain kinase family member 4
  NIMA related kinase 8
  N-terminal EF-hand calcium binding protein 1
  N-terminal EF-hand calcium binding protein 2
  nuclear receptor coactivator 5
  nuclear receptor interacting protein 3
  nucleoporin 62
  pannexin 1
  PAT1 homolog 1, processing body mRNA decay factor
  PDLIM1 interacting kinase 1 like
  periphilin 1
  PML-RARA regulated adaptor molecule 1
  POC1 centriolar protein B
  potassium channel tetramerization domain containing 13
  potassium channel tetramerization domain containing 9
  POU class 6 homeobox 2
  proline rich 20A
  proline rich 20B
  proline rich 20C
  proline rich 20D
  proline rich 20E
  protein phosphatase 6 regulatory subunit 3
  protein phosphatase, Mg2+/Mn2+ dependent 1M
  protein serine kinase H2
  PTEN induced kinase 1
  RAB guanine nucleotide exchange factor 1
  Ras association domain family member 3
  receptor accessory protein 6
  receptor interacting serine/threonine kinase 4
  Rho related BTB domain containing 2
  rhophilin associated tail protein 1
  ribosomal protein L35
  ribosomal protein S27 like
  ribosomal protein S6 kinase A6
  ring finger protein 31
  ring finger protein 32
  RNA polymerase II associated protein 3
  septin 3
  serine/arginine repetitive matrix 4
  serine/threonine kinase 11
  serine/threonine kinase 26
  serine/threonine kinase 32A
  serine/threonine kinase 32C
  serine/threonine kinase 33
  serine/threonine kinase 35
  serine/threonine kinase 36
  serine/threonine kinase 38 like
  SET and MYND domain containing 2
  SET and MYND domain containing 3
  sorting nexin 5
  spectrin beta, non-erythrocytic 4
  spectrin repeat containing nuclear envelope protein 2
  STAM binding protein like 1
  synaptonemal complex central element protein 2
  synaptonemal complex protein 3
  TANK binding kinase 1
  TAR DNA binding protein
  tensin 2
  tetratricopeptide repeat domain 9C
  THAP domain containing 1
  THAP domain containing 7
  threonyl-tRNA synthetase 2, mitochondrial
  translocase of inner mitochondrial membrane 13
  tripartite motif containing 54
  tubulin alpha 1c
  tubulin beta class I
  U2 small nuclear RNA auxiliary factor 2
  unc-45 myosin chaperone A
  unc-51 like kinase 3
  USH1 protein network component harmonin binding protein 1
  VRK serine/threonine kinase 3
  WD repeat domain 6
  WD repeat domain, phosphoinositide interacting 2
  WW domain containing adaptor with coiled-coil
  zinc finger and BTB domain containing 26
  zinc finger and BTB domain containing 8A
  zinc finger protein 276
  zinc finger protein 655
  zinc finger protein 667
  zinc finger protein 837

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.