PARK7, Parkinsonism associated deglycase

PARK7, Parkinsonism associated deglycase

• The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (Parkinson disease protein 7, Parkinson disease (autosomal recessive, early onset) 7, epididymis secretory sperm binding protein Li 67p, maillard deglycase, oncogene DJ1, parkinson protein 7, protein DJ-1, protein deglycase DJ-1, protein/nucleic acid deglycase DJ-1, DJ-1, DJ1, GATD2, HEL-S-67p,)
• NCBI Gene ID: 11315
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99497
  UNIPROT ID#>>V9HWC2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Parkinsonism associated deglycase interacts with:

• 6-phosphogluconolactonase
  AAR2 splicing factor
  acyl-CoA thioesterase 1
  adenylate kinase 3
  BCL2-associated X protein
  bolA family member 2
  bolA family member 2B
  BRISC and BRCA1 A complex member 1
  cardiotrophin like cytokine factor 1
  chloride intracellular channel 4
  chromatin target of PRMT1
  chromosome 1 open reading frame 198
  COPI coat complex subunit epsilon
  cytidine/uridine monophosphate kinase 1
  dimethylarginine dimethylaminohydrolase 1
  dimethylarginine dimethylaminohydrolase 2
  DNA polymerase delta interacting protein 2
  dual specificity phosphatase 19
  dual specificity phosphatase 28
  EF-hand calcium binding domain 6
  egl-9 family hypoxia inducible factor 3
  erythrocyte membrane protein band 4.1 like 5
  fumarylacetoacetate hydrolase domain containing 2A
  GATA zinc finger domain containing 2B
  gem nuclear organelle associated protein 4
  glutaredoxin 5
  golgi associated PDZ and coiled-coil motif containing
  haloacid dehalogenase like hydrolase domain containing 3
  HDGF like 2
  heterogeneous nuclear ribonucleoprotein A1 like 2
  histidine triad nucleotide binding protein 2
  homeodomain interacting protein kinase 1
  hornerin
  isochorismatase domain containing 2
  lactamase beta 2
  leucine rich repeat kinase 2
  LIM domain and actin binding 1
  methionine sulfoxide reductase B1
  methionine sulfoxide reductase B2
  methyl-CpG binding domain protein 3
  mitochondrial ribosomal protein S18B
  mitochondrial ribosomal protein S9
  MYC binding protein
  neudesin neurotrophic factor
  NHL repeat containing 2
  nitrilase family member 2
  OTU deubiquitinase 7B
  Parkinsonism associated deglycase
  peroxiredoxin 5
  phosphoethanolamine/phosphocholine phosphatase 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  protein phosphatase targeting COQ7
  PTEN induced kinase 1
  pyruvate dehyrogenase phosphatase catalytic subunit 1
  RAB11 family interacting protein 5
  selenophosphate synthetase 2
  selenoprotein S
  SERPINE1 mRNA binding protein 1
  spindlin interactor and repressor of chromatin binding
  thioesterase superfamily member 4
  tropomodulin 2
  tropomodulin 3
  tyrosyl-DNA phosphodiesterase 2
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin protein ligase E3 component n-recognin 5
  unk zinc finger
  WW domain binding protein 11

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.